Reducing daytime leg fluid accumulation using electrical stimulation of the legs to decrease overnight rostral fluid shift and consequent sleep apnea

Obstructive sleep apnea (OSA) is a common disorder affecting 6% of the adult population and increases risk of cardiovascular mortality. OSA occurs due to repeated full or partial collapse of the upper airway during sleep. One contributor to airway collapse during sleep is the overnight shift of fluid from the legs towards the neck where it accumulates. Increased daytime fluid accumulation in the legs magnifies this, resulting in more fluid accumulation in the neck and increased OSA severity.

Big Data Cleaning

Poor data quality is a barrier to effective, high-quality decision-making based on data. Declarative data cleaning has emerged as an effective tool for both assessing and improving the quality of data. In this work, we will address some important challenges in applying declarative data cleaning to big data, challenges that arise due to the scale, complexity, and massive heterogeneity of such data. First, we will investigate the use of domain ontologies to enhance declarative data cleaning. Second, given the dynamic nature of big data, we will develop new continuous data cleaning methods.

Microseismic imaging of hydrocarbon reservoirs treated with hydraulic fracturing

Hydraulic fracturing, also known as fracking, has become a widely used technique to extract shale gas, tight gas, tight oil, and coal seam gas from low-permeability hydrocarbon reservoirs by injecting fluid and chemicals into wellbores to create small fractures. It has significantly increase the yield of nature gas in recent years. This proposed project takes on the challenge of microseismic imaging for hydrocarbon reservoirs that are treated by hydraulic fracturing.

Eutrophication Risk Assessment and Adaptive Management Implementation in Lake Simcoe: Integration of the Watershed Processes with the Receiving Waterbody

Environmental modelling has been an indispensable tool of the Lake Simcoe restoration efforts. The proposed research aims to develop an integrated watershed-receiving waterbody modelling network that will provide a realistic platform for the evaluation of a variety of land-use management and climatic scenarios.

Designing an Autonomous Manipulator Controller for Zero-G Repair Tasks

Currently, when man-made objects in orbit around the Earth need to be disassembled or repaired, a humancontrolled robotic manipulator is used. The object in question is often not designed to be modified in this manner, and only 1 in 4 human operators at MDA (the partner organization) are able to successfully complete these notoriously challenging tasks. The goal of the proposed project is to design a computer program to learn from the successful human operators with the end result being a novel artificial intelligence that can perform these repairs autonomously, i.e.

Long-dated foreign exchange interest rate hybrid financial derivatives: modeling,calibration, pricing, and risk-management

The proposed project addresses three major challenges in modeling long-dated (maturities of 30 years or more) foreign exchange (FX) interest rate (IR) hybrid derivatives, namely

(i) the strong sensitivity of the products to the skew of the FX volatility smiles,

(ii) their very long maturities, and

(iii) popular embedded exotic features, which provide possibilities of early termination of the products.

Maximizing Benefit from Hearing Technologies for Persons with Early Stage Alzheimer’s Disease Year One

There is a strong connection between hearing loss and cognitive impairment, particularly dementia, in old age. The number of Canadians with dementia is expected to reach 9% of adults over the age of 60 by 2038. With these large numbers and limited health resources, caregiving will increasingly fall upon family and friends. Caregiving for persons with Alzheimer's disease (AD), the most common form of dementia, is frequently associated with elevated levels of emotional and physical distress.

Maximizing Benefit from Hearing Technologies for Persons with Early Stage Alzheimer’s Disease Year One

There is a strong connection between hearing loss and cognitive impairment, particularly dementia, in old age. The number of Canadians with dementia is expected to reach 9% of adults over the age of 60 by 2038. With these large numbers and limited health resources, caregiving will increasingly fall upon family and friends. Caregiving for persons with Alzheimer's disease (AD), the most common form of dementia, is frequently associated with elevated levels of emotional and physical distress.

The impacts of omega-3 fatty acids on planktonic food web processes: anexperimental approach Year One

The causal link between highly unsaturated fatty acids (HUF As) and human health is one of the hottest topics in science. Their potential to control food web dynamics in freshwater systems is a relatively recent development, but analytical difficulties have relegated research to a predominantly theoretical nature. A large deal of theoretical work was produced from my doctoral research, and breakthroughs in measuring metabolic reactions permit the testing of multiple hypotheses produced.

Role of nocturnal fluid redistribution in the pathogenesis of sleep apnea Year One

when lying down to sleep and accumulates in the neck or lung; which could be a major contributor to the development of sleep apnea in HF patients. Therefore, we aim to determine whether: 1) the relative degree of fluid shift into the neck and lungs at night is associated with the severity of sleep apnea; 2) the respiratory sounds recorded from the neck and lungs can be used to estimate the amount of nocturnal fluid accumulated in the neck or lungs. If so, a new approach for the therapy of sleep apnea would be to prevent fluid accumulation in the legs during the day.

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