A study on the application and mechanism of action of the lichen Umbilicaria muhlenbergii fractions on osteosarcoma and chondrosarcoma cells as a promising anticancer source

The purpose of this study is to determine the effect of the lichen Umbilicaria muhlenbergii fraction(s) on osteosarcoma and chondrosarcoma cells. MTT assay will demonstrate the activity of these fraction(s) against cancer cells. Appoptosis and inhibition growth analyses will be examined. The following objectives in the allocated time of five months (June 1-October 30, 2019) are planned:
1. Investigate the anticancer effects of selected fractions of U.muhlenbergii extracts on osteosarcoma and chondrosarcoma cells
2. Investigate and characterize the cell cycle control and apoptosis for the most effective lichen compound on cancerous cells
3. Detect and verify cell proliferation using a Ki-67 protein marker
The proposed experiments will allow us to compare the effect of lichen fraction(s) on bone cancerous cells. TO BE CONT’D

Faculty Supervisor:

Pedram Fatehi

Student:

Partner:

Mayo Clinic

Discipline:

Life Sciences

Sector:

Education

University:

Lakehead University

Program: