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Analytical Characterization of JZP-341 (Higher Order Structure)
York University and Jazz Pharmaceuticals are undertaking a project to accelerate development of their Leukemia drug candidate. The project will take advantage of unique technologies developed at York by Drs. Wilson and Krylov, Millisecond Hydrogen Deuterium eXchange (msHDX) mass spectrometry and Kinetic Capillary Electrophoresis (KCE), to provide a high-detail picture of Jazz Pharmaceutical’s candidate, including its unique structural and functional properties. Ultimately these data will contribute to our fundamental understanding of a set of enzymes called asparaginase in blood cancers and will provide critical support for regulatory filings leading to candidate advancement to the clinic.
Faculty Supervisor:
Derek Wilson;Sergey Krylov
Student:
Partner:
Jazz Pharmaceuticals
Discipline:
Life Sciences
Sector:
Manufacturing; Professional, scientific and technical services
University:
York University
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.