Analytical Characterization of JZP-341 (Higher Order Structure)

York University and Jazz Pharmaceuticals are undertaking a project to accelerate development of their Leukemia drug candidate. The project will take advantage of unique technologies developed at York by Drs. Wilson and Krylov, Millisecond Hydrogen Deuterium eXchange (msHDX) mass spectrometry and Kinetic Capillary Electrophoresis (KCE), to provide a high-detail picture of Jazz Pharmaceutical’s candidate, including its unique structural and functional properties. Ultimately these data will contribute to our fundamental understanding of a set of enzymes called asparaginase in blood cancers and will provide critical support for regulatory filings leading to candidate advancement to the clinic.

Faculty Supervisor:

Derek Wilson;Sergey Krylov

Student:

Partner:

Jazz Pharmaceuticals

Discipline:

Life Sciences

Sector:

Manufacturing; Professional, scientific and technical services

University:

York University

Program: