Characterization of mitochondria dynamics and metabolism in Group 2 pulmonary hypertension rat left atrial stenosis model

Pulmonary hypertension or elevated blood pressure in the lung caused by left heart diseases such as mitral valve stenosis is classified as Group 2 under the World Health Organization pulmonary hypertension classification system. Group 2 pulmonary hypertension is the most common type of pulmonary hypertension, but currently there is no approved therapies for this disease. To develop effective therapies for Group 2 pulmonary hypertension, an animal model is required. Fujimoto et al. recently developed a novel Group 2 pulmonary hypertension rat model by partially banding the left atrium with a metal clip to increase the left atrial and pulmonary venous pressure, which mimic mitral valve stenosis in human. Mitochondria, the power house of the cell, are found to be disordered in many diseases such as cardiovascular disease, neurodegenerative disease, and cancer. TO BE CONT’D

Faculty Supervisor:

Stephen Archer

Student:

Partner:

The Jikei University School of Medicine

Discipline:

Life Sciences

Sector:

University:

Queen's University

Program:

Globalink Research Award