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Cycloadditions and Annulations of Epimeric Pyrroloimidazolone Derivatives for the Synthesis of Novel Drug Leads
The proposed research aims to exploit specific applications of epimeric pyrroloimidazolones (EPIs) for the synthesis of new drug leads. Two classes of biologically active molecules will be targeted. First, EPIs will serves as intermediates toward chiral bicyclic[2.2.2]octenes with nitrogen at the bridgehead position, which are known to have a broad range of biological activities. Second, EPIs will be used to develop a series of dihydrofurans such as nucleoside analogues that have known utility for treatment of various cancers. This second series of molecules are related to Sapacitabine, a drug which is currently in advanced clinical trials for chronic lymphocytic leukemia and non-small cell lung cancers.
Faculty Supervisor:
Costa Metallinos
Student:
Partner:
Springboard Atlantic Inc.
Discipline:
Physics
Sector:
Pharmaceuticals; Health and Related Sciences & Technology
University:
Brock University
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.