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Developing A Drug-Protein Interactome for Identifying Potential Drug Targets In-situ
Our method reveals the interaction landscape of a given drug. We will generate a two-part biosensor inside living cells. The first part involves a genetically encoded reactive ‘beacon’. The second part is the drug of interest, synthetically modified with complementary reactivity to the beacon. When present together in cells, both parts chemically combine to form a chimeric ‘drug-beacon’, which will then report on the local protein environment of the derivatized drug by using proteomics. It can be applied to drug-treatment regimens on cells isolated from different patients, as part of personalized-drug discovery programs. With the successful outcome of this project, partner organization will get to benefit from the commercialization of this method by upscaling this technology to include more classes of drugs.
Faculty Supervisor:
Gagan Gupta
Student:
Partner:
I-INC Foundation for Business Development
Discipline:
Life Sciences
Sector:
Professional, scientific and technical services
University:
Toronto Metropolitan University
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.