Development and Optimization of Freeze-dried Formulations of Ga-68 based cold kit and its performance evaluation by Radiolabeling and Animal Imaging

The student will be involved in the research and development of a novel multi-dose lyophilized vial kit for the preparation of Gallium 68Ga-DOTATOC injection used for the PET imaging of neuroendocrine tumors. This novel kit compared to the currently available ready to use injectable solution, has better shelf life and can be easily shipped to a radiopharmacy where the vial can be radiolabeled by adding the 68Ga-chloride eluted from a generator or cyclotron, and then distributed to hospitals and other nuclear medicine clinics. Availability of freeze-dried kit formulations for the preparation of 68Ga-DOTATOC is expected to increase the scope of 68Ga-based agent for PET imaging and expand the availability for more patients to receive the cancer treatment.

Faculty Supervisor:

Hadis Zarrin

Student:

Partner:

Jubilant Radiopharma

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

Toronto Metropolitan University

Program: