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Enhancing Quarter Horse Welfare Through Novel Identification of ß2-agonist Use
A readily identifiable biomarker for ß2-agonist use is desperately needed to maintain competition integrity and ensure welfare of performance horses. Our overarching hypothesis is that chronic ß2-agonist administration induces an energetic switch in skeletal muscle, resulting in impaired mitochondrial function and elevated oxidative stress which, in turn, up-regulates a single or group of metabolites that is unique to chronic ß2-agonist administration. This timely and industry-applicable hypothesis will be tested in the following 2 objectives:
Objective 1: Identify a single or group of metabolites that are differentially expressed following chronic ß2-agonist administration.
Sub-Objective 1: Determine timing of differential expression of metabolites identified in Objective 1 after the onset of drug administration.
Objective 2: Definitively characterize the impacts of chronic ß2-agonist administration on cardiac and skeletal muscle health and responses to acute exercise stress in Quarter Horses.
Faculty Supervisor:
Wendy Pearson
Student:
Partner:
Texas A&M University
Discipline:
Life Sciences
Sector:
Education
University:
University of Guelph
Program:
Globalink Research Award
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.