Related projects
Discover more projects across a range of sectors and discipline — from AI to cleantech to social innovation.
Formulation and Toxicology of Bone-Targeting Nanoparticles – Year two
Bones undergo a renewal process by replenishing calcium mineral through a cellular process known as remodeling. Usually, it happens in a balanced manner, but in many bone diseases, the remodeling process is increased with regional bone metabolism. Bisphosphonate (BP) drugs selectivity and strongly bind to bone mineral and become incorporated at active sites of bone turnover in an increased amount. Accordingly, we have exploited that increased bone metabolism to develop novel bone imaging tracers of metabolism based on BP-conjugated superparamagnetic iron oxide nanoparticles (BP-SPIONs), which localize to remodeling bone surfaces for detection by magnetic resonance imaging (MRI). The current project aims to establish and characterize a stable formulation of the proprietary OsteoMetabolix Pharma BP-SPION, with subsequent toxicity testing in-vitro in cell culture, and in-vivo in rodents (rats), to ascertain minimum effective dose and expected adverse effects of BP-SPIONs as a potential non-ionizing alternative to the technetium radionuclide bone scan.
Faculty Supervisor:
Raimar Loebenberg
Student:
Partner:
Osteometabolix Pharmaceuticals Inc
Discipline:
Life Sciences
Sector:
Health and Related Sciences & Technology
University:
University of Alberta
Program:
Elevate
Current openings
Find the perfect opportunity to put your academic skills and knowledge into practice!
Find Projects
International
Load More
International
Load More
Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.