Glycopolymer based Silicon Quantum Dots – Functionalization and Biological evaluation

Silicon quantum dots (SiQDs) are semiconductor nanoparticles with sizes ranging from 1 to 10 nm that show great promise for photonics, microelectronics, and fluorescent bio-imaging considering their ability to fluoresce from blue to near infrared light. In comparison to conventional quantum dots (which can release toxic metals), Si quantum dots are expected to be safer and more stable for use in biomedical engineering applications.
This project aims at functionalization of SiQDs with glycopolymers and evaluate their toxicity in vitro. The study will assess several parameters such as concentration, compositions, sizes and surface charges of the glycofunctionalized nanoparticles and their impact on cellular update and viability. Different cell lines, a range of assays and techniques will be used to assess the internalization of the nanoparticles, their distribution within the cells and their cellular toxicity. The mechanism of uptake of the nanoparticles within cells will also be studied.

Faculty Supervisor:

Ravin Narain

Student:

Partner:

Université de Lorraine

Discipline:

Engineering

Sector:

Education

University:

University of Alberta

Program: