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Identification and validation of novel microvascular smooth muscle cell targets for the treatment of heart failure
In response to heart injury, blood vessels throughout the body constrict. While this response maintains blood pressure, it strains an already injured heart. Reducing blood vessel constriction after heart injury, therefore, is beneficial. Current medications do not target the root cause of the blood vessel constriction. We have identified keys parts of a signalling complex that control blood vessel constriction, but many parts remain unknown. This project will identify the unknown components of the signalling complex. We will then use screening methods to identify medicines that alter this complex. We will test these medicines for effects on blood vessel constriction. Finally, medicines that alter blood vessel function will be tested for benefits in a model of heart failure.
Faculty Supervisor:
Steffen-Sebastian Bolz
Student:
Partner:
Qanatpharma Canada Ltd.
Discipline:
Life Sciences
Sector:
Professional, scientific and technical services
University:
University of Toronto
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.