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Investigating the Potential of Hair Follicle-Derived Mesenchymal Stem Cells (HF-MSCs) for Neural Differentiation
Mesenchymal stem cells (MSCs) hold immense potential for regenerative therapies, primarily due to their ability to differentiate into various cell types and their immunomodulatory properties. While traditionally derived from bone marrow, adipose tissue, or umbilical cord, these sources pose significant challenges, including cost, invasiveness, and availability. Recent studies suggest that human hair follicles (HF) offer a non-invasive, autologous, and accessible source of MSCs and that HF-derived MSCs share key characteristics with traditional MSCs, including multipotency and surface marker expression. In this project we will explore the potential of HF-MSCs to differentiate into neural cell types, including dopaminergic neurons with the goal of producing a foundation from which the feasibility of using HF-MSCs in neural regenerative therapies can be explored.
Faculty Supervisor:
Melanie Alpaugh
Student:
Partner:
Acorn Biolabs
Discipline:
Life Sciences
Sector:
Professional, scientific and technical services
University:
University of Guelph
Program:
Accelerate
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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.