Investigation of Recrystallization Inhibitory Effect of Terpolymer Nanoparticles in Ethylcellulose Membrane for Amorphous Solid Dispersions of Drugs with Low Solubility

Poor water-solubility limits the total use of the drug in the human body of many recently discovered drugs. Recently, Amorphous Solid Dispersion (ASD) technique is being used as an efficient way to enhance solubility of poorly soluble drugs which are prevalent in pharmaceutical industry while providing sustained release, however the instability of ASD may cause recrystallization of the drug, decreasing the utility and may cause side effects. Controlled release (CR) coating with a novel terpolymeric nanoparticle (TPN) as pore forming material is proven to be an effective way to reduce the side effects, and the recrystallization inhibition effect of the TPN as pore former should be studied, benefiting the partner organization with new insights to controlled release formulations.

Faculty Supervisor:

Xiao Yu Shirley Wu

Student:

Partner:

Candoo Pharmatech Company Inc.

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: