Microbiome-endocannabinoidome role in response to prebiotic and probiotic interventions in a Murine Model of Diet-Induced Metabolic Syndrome

Probiotics could help prevent or treat metabolic-related conditions such as dyslipidemia or Type 2 Diabetes. Combination of probiotics with prebiotic fibers could potentiate the positive effect of these treatments. Our hypothesis is that probiotic strains, coupled with brown algae prebiotic fibers, may hold potential for modulating lipid metabolism, which might represent an interesting avenue for the management of diabetes and metabolic syndrome (MetS) through non-pharmacological treatments. In previous work, we established a murine model of diet-induced metabolic syndrome and type-2 diabetes (T2D) and treated mice with BIOK+ formulation as well as new probiotic strains, with or without prebiotic algae preparation. In this Mitacs Accelerate project, we reinvest samples collected from these animals to investigate the role of the gut microbiome and tissue endocannabinoidome response to the prebiotic and probiotic combinations.

Faculty Supervisor:

Frédéric Raymond;Cristoforo Silvestri

Student:

Partner:

Bio-K Plus International Inc;Kerry (Canada) Inc.

Discipline:

Life Sciences

Sector:

Manufacturing; Professional, scientific and technical services

University:

Université Laval

Program: