MITACS Globalink Research Internship – Investigation of Cerebral Cortex Development Under the Influence of Pharmacological Treatments

This project explores how the anti-epileptic drug valproic acid (VPA) may affect early brain development during pregnancy. While VPA is known to increase the risk of neurodevelopmental conditions such as autism and learning difficulties in children, the exact effects on the developing human brain are not well understood. To study this, the project uses a new laboratory human brain model called “cerebroids”. These models closely mimic how the brain normally develops, allowing researchers to study VPA’s effects in more detail and under realistic conditions. The project will look at how VPA influences brain cell growth, movement, and gene activity. The findings will help improve understanding of how certain medications may impact the brain during pregnancy and could guide safer treatment strategies. This research strengthens collaboration across institutions by combining advanced tissue models, imaging, and genetic analysis, and supports the broader goal of improving maternal and child health through evidence-based science

Faculty Supervisor:

Guy Rousseau

Student:

Partner:

University of Aberdeen

Discipline:

Life Sciences

Sector:

Education

University:

Université de Montréal

Program: