New Inhibitors of HIV Infection

A new target on HIV gp120 for interventive drug therapy has been discovered and a company,

ViroCarb, initiated to screen for small molecule inhibitors that bind in this site. Two structurally

related inhibitors have been isolated from chemical libraries. This internship is to determine the scope

of these inhibitors, whether they are able to inhibit all HIV strains including clinical strains and drug

resistant strains, the intern will also use a cell binding assay to confirm the mechanism of action which

should be via inhibition of the virus binding to the target cell. These assays will be used to determine

improvements in inhibition which result from chemical modification of the newly discovered

inhibitors.

Faculty Supervisor:

Alan Cochrane

Student:

Partner:

ViroCarb Inc

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Toronto

Program:

Accelerate

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