Quantification of Cerebrospinal Fluid and Plasma Amyloid-ß 34, 37, and 38: Correlation with Positron Emission Tomography Imaging and Alzheimer’s Disease Progression

This project focuses on improving how we detect Alzheimer’s disease early by measuring lesser-known, protective forms of the amyloid-ß protein—Aß34, Aß37, and Aß38—in blood and cerebrospinal fluid. These shorter forms are thought to help clear the harmful ones that build up in the brain and cause damage. Using a highly sensitive method called single molecule array, I’ll measure these proteins in samples from the TRIAD cohort and compare them with existing Alzheimer’s markers and brain imaging data. The aim is to develop a simple and reliable toolkit for early diagnosis, which could support both research and clinical teams at the participating institutions in identifying the disease sooner and more accurately.

Faculty Supervisor:

Pedro Rosa-Neto

Student:

Partner:

Göteborgs universitet

Discipline:

Life Sciences

Sector:

Health and Related Sciences and Technology; Biotechnology

University:

McGill University

Program:

Globalink Research Award

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