Rational programming of antigen structure using DNA nanotechnology to enhance vaccine immunogenicity

This project seeks to investigate how the nanoscale structure and arrangement of antigens influences immune recognition and vaccine efficacy. Using DNA nanotechnology and precise structural engineering, we aim to establish a structure-function paradigm linking antigen conformation and valency to immunogenicity. Using cancer vaccines as a stringent testbed of tumor antigens, the design rules established under this project provide a promising foundation for potentially translatable optimization of nanovaccines for a variety of conditions. A deliberate emphasis upon nanoparticle modularity is a key component of this project and its aims to provide a streamlined approach to nanovaccine development. Enabling flexible integration of a diverse library of antigens allows for more rapid prototyping and high-throughput evaluation of immune interactions. This work aims to define a set of fundamental principles concerning antigen structure and arrangement that can guide the rational engineering and programming of future nanovaccines.

Faculty Supervisor:

Leo Chou

Student:

Partner:

Ohio State University

Discipline:

Engineering

Sector:

Biotechnology; Nanotechnology; Pharmaceuticals

University:

University of Toronto

Program: