Research And Development of Heat Flowable High-Strength Bioabsorbable Bone Adhesive

The primary project objective of this proposal is to evaluate company’s absorbable polymeric (PCL/PLLA) performance as the heat flowable bone repair adhesive materials. The expected overall project outcome is a unified surgical delivery tool and implantable adhesive that provides the customers/users (surgeons/patients/hospitals) of this device a surgical repair product. Materials and Methodology: Material Description: The UMass patent covers a blend of two well-known absorbable materials Polycaprolactone (PCL) and poly(L-lactide) (PLLA). The blend used in the UMass goat study and the materials being proposed are a 90% PCL 10% PLLA. The material patent is licensed from University of Massachusetts. Polycaprolactone (PCL) is a biodegradable polyester with a low melting point of around 60°C and a glass transition temperature of about ?60°C. The most common use of polycaprolactone is in the manufacture of speciality polyurethanes. Polycaprolactones impart good water, oil, solvent and chlorine resistance to the polyurethane produced. It is used as a bioabsorbable material in a number human use implantable devices. In particular it is especially interesting for the preparation of long term implantable devices, owing to its degradation which is even slower than that of polylactide.

Faculty Supervisor:

Amyl Ghanem

Student:

Partner:

Dartmouth Medical Research Limited

Discipline:

Engineering

Sector:

Professional, scientific and technical services

University:

Dalhousie University

Program: