Synthesis and Evaluation of Reversible Covalent-Binding AntiCancer Drugs

Designing new anticancer agents using structure based drug design and the 3D structure of the biological target
is becoming an increasingly important field of study. The main objective of this project is to develop and identify
anticancer drug candidate(s) for advanced preclinical testing, with the end goal of identifying drug candidates
suitable for clinical trials and commercialization. Currently, we have synthesized several novel drug candidates
designed to mitigate the increased toxicological effects observed in a significant proportion of patients receiving
current therapies. Meanwhile we will also investigate whether our designer molecules will have enhanced
anticancer properties over similar anticancer agents during early phase pre-clinical testing. This research project
will provide a better understanding on how our designer molecules behave as anticancer agents.

Faculty Supervisor:

Geoffrey Tranmer

Student:

Partner:

North Forge

Discipline:

Life Sciences

Sector:

Education; Management of companies and enterprises; Professional, scientific and technical services

University:

University of Manitoba

Program: