Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

29 670 projets achevés

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4990
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801
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663
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825
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8841
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9197
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95
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568
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Projets par catégorie

Optimized use of UM171 and derived molecules for the next generation of genetically engineered blood stem cell grafts in high-risk leukemia therapy.

Hematopoietic stem cells (HSCs) have the ability to reconstitute hematopoiesis by giving rise to all blood lineages without exhaustion. Despite the widespread clinical application of HSCs, the success of HSC transplantations relies mainly on the availability of suitable donors and adequate grafts. Obtaining high-quantity and quality hematopoietic grafts for curing hematological and non-hematological diseases remains still challenging. We have previously reported that the small compound UM171 stimulates the expansion of functional long-term HSCs and also contributes on expanding immuno-modulatory cells. The recent knowledge on the UM171 mechanism of action will allow us to further improve the HSCs expansion conditions and to evaluate new analogs of UM171 for their improved properties. Defining optimal expansion conditions for HSCs will provide the milestone to further genetically engineer these cells and offer alternative therapies to patients. For instance, production of CAR expressing effector cells will provide an improved approach with the potential to treat acute myeloid leukemia. Thus, this proposal seeks to better understand the factors influencing ex vivo HSC culture and support the development of engineered HSC grafts via our expertise and of ExCellThera’s expansion and cell engineering platform.

Voir la description complète du projet
Superviseur du corps professoral :

Guy Sauvageau

Étudiant :

Partenaire :

ExCellThera

Discipline :

Life Sciences

Secteur :

Agriculture; Health and Related Sciences & Technology; Professional, scientific and technical services

Université :

Université de Montréal

Programme :

Elevate

Évaluation de systèmes d’inspection visuelle intelligents afin d’améliorer l’efficacité de la production du processus de fabrication de capots de cuve d’électrolyse de la compagnie Estampage JPL

La compagnie Estampage JPL Ltée et le Laboratoire des Technologies de la Biomasse (LTB), visent à améliorer le processus de transformation de l’aluminium. Le projet se consacrera à développer des technologies d’inspection visuelles intelligents (capteurs, senseurs, caméras, compteurs intelligents, etc.) pour être capable de diagnostiquer les problématiques de qualité de la matière première et de réduire la quantité des produits non-conformes. L’automatisation de l’usine à travers des technologies de pointe permettra un contrôle adéquat des variables importantes dans chaque étape du processus et les données récoltés pourront faciliter la gestion et permettra prendre de décisions plus rapides et plus précises au sein de la compagnie.

Voir la description complète du projet
Superviseur du corps professoral :

Jean-Michel Lavoie

Étudiant :

Partenaire :

Estampage JPL

Discipline :

Engineering

Secteur :

Manufacturing

Université :

Université de Sherbrooke

Programme :

Accelerate

Targeting achievement in higher-order thinking and STEM: An interprofessional approach

This proposed research investigates the use of ThUMP by classroom educators to foster high order thinking through authentic and meaningful practice activities. Research suggests that practice is require to obtain expertise in complex subject areas such as STEM (Science, Technology, Engineering and Mathematics). ThUMP allows educators to author practice activities that students can access using mobile devices. This proposed research adopts a design based approach in order to provide feedback / feed forward to the Mathtoon’s developers. Findings from this study will be shared in recognized international conferences and publications

Voir la description complète du projet
Superviseur du corps professoral :

Susan Crichton

Étudiant :

Partenaire :

Mathtoons Media Inc

Discipline :

Sociology

Secteur :

Professional, scientific and technical services

Université :

University of British Columbia - Okanagan

Programme :

Accelerate

Exploring Unsupervised Domain Adaptation Methods for Automated Linear Disturbance Mapping

In the Canadian boreal forest region habitat fragmentation due to linear disturbances (roads, seismic explora-tion, pipelines, and energy transmission corridors) is a leading cause for the decline of wood-land caribou (Rangifer tarandus) – boreal population; and as a result, a deep understanding of linear disturbances (amount, spatial distribution, dynamics) has become a research and forest management priority in Canada. An ideal tool in mitigating and restoring the impact of linear disturbances is a way to automatically generate maps detailing forest region habitat fragmentation. As a result, the focus of this project is to develop machine learning ap-proaches to automatically create maps of linear disturbances, where these maps are produced from satellite data covering the area of interest.

Voir la description complète du projet
Superviseur du corps professoral :

Christopher D Storie

Étudiant :

Partenaire :

Hatfield Consultants

Discipline :

Computer science

Secteur :

Professional, scientific and technical services

Université :

University of Winnipeg

Programme :

Accelerate

Personal Health Information Software Platform – Data Exposure and Referential Integrity Investigations for Electronic Medical Record Integration Development for Seamless Hospital Use

TAMVOES is a personal health record (PHR) software platform that seeks to help better manage an individual’s health by empowering them to collect and securely store copies of their health history, allergies, vitals and appointments online. They have an opportunity to increase their customer base by extending their platform to hospitals and large clinics, especially those using electronic medical records (EMR) in their operations. The Mohawk College mHealth and eHealth Development and Innovation Centre (MEDIC) will help to investigate how a major EMR used by a large Southern Ontario hospital that is a potential client of TAMVOES enables data integration through Fast Healthcare Interoperability Resources (FHIR) protocols. MEDIC will use the findings and consider stakeholder (TAMVOES, patients, hospital, and EMR platform) needs to develop PHR to EMR software integrations. The project will help TAMVOES sell their EMR integrated platform to hospitals and larger clinics who use two major EMRs.

Voir la description complète du projet
Superviseur du corps professoral :

Doug Ward

Étudiant :

Partenaire :

TAMVOES Health Inc

Discipline :

Computer science

Secteur :

Health and Related Sciences & Technology

Université :

Mohawk College of Applied Arts and Technology

Programme :

Accelerate

Applying the RE-AIM Framework to Evaluate a Story-Based Positive Youth Development Program for Young Ice Hockey Players

Despite the numerous benefits of participating in child and youth sport, they not guaranteed. Purposeful efforts must be made to ensure that sport offerings are age appropriate, promote engagement and enjoyment, and involve quality social relationships. This project represents a partnership with the objective of implementing and evaluating a story-based positive youth development (PYD) program—The 1616 Program—for young hockey players (10 years of age) in North America. The aim of the 1616 Program is to use elite hockey players as role models—through story-telling—to serve as motivating agents to introduce and engage young athletes with important concepts pertaining to PYD. This Mitacs funded project is founded in the RE-AIM framework and PYD literature to ensure that the 1616 Program aligns with the founder’s vision for the program while simultaneously is fulfilling the intended outcomes and needs of the end-users.

Voir la description complète du projet
Superviseur du corps professoral :

Luc J Martin;Jean Côté

Étudiant :

Partenaire :

Ladd Foundation

Discipline :

Sociology

Secteur :

Other services (except public administration)

Université :

Queen's University

Programme :

Accelerate

Ryan Underwood Mitacs Elevate with General Fusion: Investigation of Novel Photon Detection Devices for Fusion Diagnostic Applications

General Fusion is pursuing a fast, efficient, and collaborative path to practical fusion power. Its vision is a world with clean, limitless energy, and General Fusion’s mission is to deliver it using its proprietary Magnetized Target Fusion technology. General Fusion is building a Fusion Demonstration Plant to prove this technology and will require numerous state-of-the-art fusion fuel measurement tools. TRIUMF has research experience in relevant electronics and measurement tools. The applicant will work with TRIUMF and General Fusion to investigate a new type of electronic device that shows promise for three different tools that measure temperature and composition of the fusion fuel. This research project will help determine the feasibility of this technology for these applications, which will benefit both TRIUMF and General Fusion.

Voir la description complète du projet
Superviseur du corps professoral :

Fabrice Retiere

Étudiant :

Partenaire :

General Fusion Inc

Discipline :

Physics

Secteur :

Manufacturing; Professional, scientific and technical services; Utilities

Université :

TRIUMF INC.

Programme :

Elevate

Optimisation de la diète et du procédé de transformation

NEXFID est une start-up de biotechnologie qui compte produire et commercialiser les protéines et acides gras de haute qualité provenant de l’élevage d’insectes tout en valorisant les déchets organiques. La farine et l’huile d’insecte sont des alternatives durables et écologiques au soja et à la farine de poisson. La production se situera dans une dynamique de symbiose industrielle où les déchets d’agroindustriels seront utilisés comme intrants dans la production des larves. La bioconvertibilité de ces déchets représente l’élement central de la production et c’est dans ce contexte que NEXFID compte rentrer en production pilote afin de valider et optimiser certains paramètres de production. L’objectif de la phase de recherche se situe trois niveaux.
• Évaluer et optimiser la bio-convertibilité des déchets organiques qui seront valoriser
• Optimiser le procédé de transformation
• Évaluer la qualité et la performance de notre farine et de notre engrais
Nous comptons également envoyer les échantillons de notre farine et engrais à nos clients potentiels afin d’évaluer leurs performances, leurs qualités et leurs adaptabilités à leurs équipements de production. Le but sera de signer des contrats de ventes avant de commencer la production industrielle

Voir la description complète du projet
Superviseur du corps professoral :

Marie-Hélène Deschamps

Étudiant :

Partenaire :

NEXFID

Discipline :

Life Sciences

Secteur :

Manufacturing

Université :

Université Laval

Programme :

Accelerate

Continuous flow chemistry synthesis of Vitamin C

Natural health products have become integral to many personal routines and the Canadian economy as a $9 billion industry. But recent problems within China and India, which currently have a stranglehold on raw materials, are endangering the health of this growing sector. Replacing foreign sources with traditional batch production means is foolish since domestic labor costs are not competitive. By utilizing the high-tech method of production of continuous flow chemistry, we can achieve a cost-effective and competitive production method. We chose to investigate the production vitamin C since it is the most-consumed nutraceutical ingredient by mass. If successful, we can open a new paradigm of vitamin C synthesis with potentially trivial achievement of pharmaceutical-grade purity, minimal labor input and near-zero environmental impact. Furthermore, this technology can be implemented into other key vitamins and even pharmaceuticals which not only has obvious commercial implications but can contribute significantly to establishing healthcare independence.

Voir la description complète du projet
Superviseur du corps professoral :

Kalindi D. Morgan;Andrea Gorrell

Étudiant :

Partenaire :

EluciDx

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Northern British Columbia

Programme :

Accelerate

A Finite Element Framework for Anisotropic Material Constitutive Modelling of Additive Manufactured Superalloy Parts

Additive Manufacturing is a rapidly growing technology in the gas turbine industry. Its numerous advantages allow for the design of complex shapes which have not been possible in the past, using conventional manufacturing method. The parts could be manufactured on demand, with reduce cost and lead time. Selective Laser Melting is the common method to additive manufacture metal super alloy parts for combustors and turbines. The anisotropic microstructure from the printing process pose a challenge to numerical simulation and conventional predictive models. To accurately predict the mechanical integrity of the part, an improved constitutive material model that could accurately predict the part non-linear deformation after yielding is crucial. It’s especially important to couple this non-linear deformation model with the thermo-mechanical loading where the temperature could be in phase or out of phase with the loading
This project aims to create an efficient and accurate non-linear deformation for predicting the mechanical deformation of the SLM parts, theirs associated stress and strain, in preparation for future mechanical integrity assessment model. Using mathematical model and empirical factors from material testing, an efficient predictive tool will be developed to extend the current capability within Abaqus finite element software.

Voir la description complète du projet
Superviseur du corps professoral :

Mathias Legrand

Étudiant :

Partenaire :

Siemens Energy Canada

Discipline :

Engineering

Secteur :

Information and cultural industries; Professional, scientific and technical services

Université :

McGill University

Programme :

Accelerate

Calibration of numerical model of the three-stage corrosion process of galvanized steel reinforcements in Mechanically Stabilized Earth

Bridge abutments are commonly built with a construction technology called Mechanically Stabilized Earth that provides structural soundness. The core element is a composite material that alternates layers of backfill soil with layers of galvanized steel reinforcements. Although the structural design has been well developed since its introduction in the construction practices, the degradation of the reinforcements due to corrosion has not been considered in detail and it is a major failure mechanism. A numerical model of the three-stage corrosion process of galvanized steel in Mechanically Stabilized Earth has been developed. The model considers variations in properties of the soil such as temperature, oxygen availability and salts content. However, field data from several bridges in British Columbia is about to be collected with the Ministry of Transportation and Infrastructure. The information gathered will be used to calibrate the model to its most realistic prediction capability so it gives reliable estimations that can be used for risk assessment of the structures.

Voir la description complète du projet
Superviseur du corps professoral :

Akram Alfantazi

Étudiant :

Partenaire :

Transportation and Infrastructure BC;Atlantic Industries Limited (NB)

Discipline :

Engineering

Secteur :

Construction; Transportation (excluding aerospace)

Université :

The University of British Columbia

Programme :

Accelerate

Optimization of Isolation and Purification of the Microbe-to-Plant Signal Bacillin 20 from Bacillus thuringiensis

Plants are always associated with a well-coordinated and beneficial community of microbes – the phytomicrobiome; this plus the associated plant forms the holobiont, the entity that provides crop yield. There is considerable communication between the phytomicrobiome and the plant, often through signal compounds. Bacillin 20 is a small protein (a peptide) produced by a Bacillus thuringiensis strain and discovered by the Smith laboratory. It improves plant ability to tolerate stress when applied at very low concentrations. One plant response to stress is accelerated flowering, leaving longer time for grain production. The proposed work will evaluate the potential for bacillin 20. This work focuses on bacillin 20 mature and widely used technology (both relatively inexpensive and environmentally friendly) for the production of a wide range of agricultural crops (extending all the way from soybean to cannabis). This work will make Canada a global leader in the area of microbe-based biostimulants. Technologies that assist crops in dealing with stress will play a key role in the longer-term development of climate change resilient agriculture.

Voir la description complète du projet
Superviseur du corps professoral :

Donald Smith

Étudiant :

Partenaire :

CXC

Discipline :

Life Sciences

Secteur :

Agriculture; Professional, scientific and technical services

Université :

McGill University

Programme :

Accelerate

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