Characterization of Simple In Vivo Models of Charcot Marie Tooth (CMT) Disease
Modelis is a drug discovery platform company focused solely on rare, genetic diseases. Our unique approach combines genetically-engineered worms which are ‘avatars’ of human patients, with high-throughput drug screening. This results in a dramatically accelerated drug discovery process. Our platform is perfectly suited for genes that are evolutionarily and functionally conserved such as FIG4, and the related disorder Charcot-Marie-Tooth 4J (CMT4J). This project will focus on engineering and phenotyping worm ‘avatars’ for high-throughput drug screening and performing the drug screens in worms. The best candidate hits will further enter a preclinical pipeline using patients’ cells.
Voir la description complète du projetAlex Parker
Modelis inc.
Life Sciences
Professional, scientific and technical services
Université de Montréal
Accelerate
