Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30156 projets achevés

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Projets par catégorie

Evaluating myogenic cell force generation

The intention of this project is inquiry into the role of force signaling in skeletal muscle repair. Before muscle damage, muscle stems cells that are yet to be incorporated in the muscle fibers are relatively inactive, but when injury occurs they can multiply and are recruited to the site of damage. Many aspects of the cell and its surroundings could be involved in this process, such as points of contact between cell and substrate, the protein coating of the substrate, the cell’s cytoskeletal interaction with the substrate and substrate stiffness. Using different methods of microscopy, the intention is to carry what is known about myogenic cell and substrate interactions on a two dimensional gel format to a three dimensional gel format, and eventually in the context of a living muscle tissue. By doing this the hope is that the role of force signaling’ in muscle repair is made clearer as well as to understand why muscle stem cells lose their potency for repair as we age.

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Superviseur du corps professoral :

Penney Gilbert

Étudiant :

Partenaire :

Westfälische Wilhelms-Universität Münster

Discipline :

Life Sciences

Secteur :

Life Sciences (not health); Biotechnology; Health and Related Sciences & Technology

Université :

University of Toronto

Programme :

Globalink Research Award

In vitro degradation of polymeric drug carrier for sustained release of therapeutics

The focus of this study is on the understanding of degradation rate and mechanism of the polymeric drug carrier for intra-articular injection of therapeutics. For this aim a radical-containing and enzyme-containing medium will be used to accelerate the degradation conditions. At each time point the mass loss and Tg of the hydrogels will be calculated and the structure and molecular weight of the degradation products will be characterized. The potential degradation mechanism will be proposed for the polymers.

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Superviseur du corps professoral :

Brian Amsden

Étudiant :

Partenaire :

Eupraxia Pharmaceuticals

Discipline :

Engineering

Secteur :

Manufacturing

Université :

Queen's University

Programme :

Accelerate

Conception de l’extension en porte-à-faux de la corde supérieure des poutrelles en acier

Le projet de recherche sera réalisé en partenariat avec le Groupe CANAM, un important concepteur et fabricant de poutrelles en acier en Amérique du Nord. Il vise à concevoir une méthode de calcul de la résistance pondérée en flexion d’extensions en porte-à-faux qu’il est courant de rencontrer sur les poutrelles en acier que fabrique l’organisme partenaire. Le calcul de la résistance de ces extensions en porte-à-faux ne peut être effectué avec les méthodes simples qui sont disponibles dans les codes ou la littérature en raison de la complexité de la section des extensions, qui peut être uni-symétrique ou asymétrique, et des conditions de chargement et de retenue latérale qui sont particulières. Ces caractéristiques affectent la résistance des extensions et doivent être prises en compte lors de la conception. TO BE CONT’D

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Superviseur du corps professoral :

Robert Tremblay

Étudiant :

Partenaire :

Canam Bâtiments et Structures Inc

Discipline :

Engineering

Secteur :

Manufacturing

Université :

École Polytechnique de Montréal

Programme :

Accelerate

Engaging people experiencing poverty in poverty reduction initiatives

Across Canada, many provinces and municipalities are struggling to address poverty in their communities. Communities are attempting to address poverty with poverty reduction strategies. With a lack of literature to support these attempts, it is difficult for communities to best address poverty and to best engage people experiencing poverty in their poverty reduction initiatives. Results from this study will provide a model of engagement for communities looking to engage people experiencing poverty in solutions to address poverty. Results from this study will also support the creation and implementation of a Stakeholder Forum (a lived experience of poverty table) at EndPovertyEdmonton in which members will work with EndPovertyEdmonton to create, implement, and evaluate solutions to end poverty.

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Superviseur du corps professoral :

Maria Mayan

Étudiant :

Partenaire :

United Way of the Alberta Capital Region

Discipline :

Sociology

Secteur :

Public Service, Policy, and Governance; Other

Université :

University of Alberta

Programme :

Accelerate

Predicting In-patient Discharges to Identify Bed Availability for Housekeeping During Emergency Department Surge Using Machine Learning Algorithms

Prolonged patient waiting times for an inpatient bed in the Emergency Department (ED) is considered a global crisis and most cited reason for the ED crowding. Inability to move admitted patients from the ED to an inpatient bed due to capacity shortage and inefficiencies in patient-flow affects patient care and patient experiences. Housekeeping is crucial in patient-flow from ED to inpatient bed. When a patient leaves a bed (for example, discharge), housekeeping staff must clean and sanitize the bed. Knowing when the beds will be available during ED surge can facilitate the process of bed cleaning and hopefully reduce ED wait times. This research aims to apply machine learning algorithms to predict inpatient discharges during ED surge to identify the number of beds available in next four hours. This will enable housekeeping staff to plan ahead and reduce ED wait times.

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Superviseur du corps professoral :

Michael Carter

Étudiant :

Partenaire :

Sodexo Canada

Discipline :

Engineering

Secteur :

Administrative and support, waste management and remediation services

Université :

University of Toronto

Programme :

Accelerate

Investigating the robustness of gut microbial functions across primates

It remains unclear which factors drives variation in the gut microbiome across humans. Past work has taken an evolutionary perspective and compared the gut microbiome of humans on Western diets to wild primates and humans on non-Western diets and identified particular microbes which are at different abundances. However, the focus of these studies has mainly been on which microbes are present and not what these microbes are doing. By applying my tool, PICRUSt2, to these gut microbiome sequencing datasets I will generate predicted functional profiles and identify potential microbial functions that have diverged in abundance across primate evolution. In addition, I will expand upon my host supervisor’s recently developed metrics of functional redundancy to determine how microbial functional redundancy has diverged across primate evolution. I expect to identify microbial functions linked to diet that have diverged along the human lineage along with functions that remain redundant along the human lineage, possibly due to selective pressure.

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Superviseur du corps professoral :

Morgan Langille

Étudiant :

Partenaire :

Tel Aviv University

Discipline :

Life Sciences

Secteur :

Life Sciences (not health); Health and Related Sciences & Technology; Biotechnology

Université :

Dalhousie University

Programme :

Globalink Research Award

Investigation of ship capabilities on ice management effectiveness using a marine simulator

This project uses a marine simulator to investigate how different ship capabilities and configurations affects how well sea ice can be managed. The experiment looks at how changing various aspects of the ship (e.g. thruster power, ice class, propulsion system) affects how well the ship captain can perform the ice clearing operations. The project uses volunteer ship drivers to execute an ice management scenario using one of the vessel configurations. The performance metrics assess the captains’ ability to clear ice from the area of interest while staying within safe operational limits. The project expects to find a significant change in ice management effectiveness as the capabilities of the ships are increased. The partner organization from the study of azimuthing pods, which is a technology that will be a part of this project.

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Superviseur du corps professoral :

Brian Veitch

Étudiant :

Partenaire :

Virtual Marine

Discipline :

Engineering

Secteur :

Ocean Tech; Energy and Utilities; Information and Communications Technology

Université :

Memorial University of Newfoundland

Programme :

Accelerate

Community Tables: Engaging Neighbors! [Internship Pair #1]

The United Way of Greater Victoria (UWGV) is spearheading a collaborative community development project with the UVIC Office of Community-Based Research (OCBR) and BC Healthy Communities entitled Community Tables: Engaging Neighbors. Four Mitacs OCBR Interns (plus a fifth supporting intern) will work with 3 neighborhoods and on a broader Capital Region District level with citizens from all walks of life to identify community assets, capacities and visions for change using participatory research, survey, mapping and action planning. Specific attention in the research and action planning will be paid to the United Way’s three priorities for 2011-2014-From Poverty to Possibility, All that Kids Can Be; and Healthy People, Strong Communities.

Voir la description complète du projet
Superviseur du corps professoral :

Leslie Brown

Étudiant :

Partenaire :

United Way - Greater Victoria

Discipline :

Sociology

Secteur :

Health and Related Sciences & Technology

Université :

University of Victoria

Programme :

Accelerate

Propriétés immunomodulatrices de l’activité bactéricide de la phospholipase A2-IIA sécrétée sur le microbiote

Nous étudions les interactions entre une protéine bactéricide, la phospholipase A2-IIA sécrétée (sPLA2-IIA), et la flore microbienne intestinale (microbiote) afin d’en évaluer l’effet sur le système immunitaire. Nous avons observé que des souris transgéniques exprimant constitutivement la sPLA2-IIA humaine (sPLA2-IIATGN) présentent un important désordre immunitaire. En tentant de vérifier l’hypothèse que ce désordre est causé par l’activité bactéricide de la sPLA2-IIA sur le microbiote, nous avons mesuré par séquençage d’importantes différences dans la composition du microbiote intestinale des souris sPLA2-IIATGN et leur contrôle. Nous avons également découvert qu’éliminer cette flore par l’administration d’antibiotiques réduit considérablement ce désordre immunitaire. Il est connu que la flore peut moduler l’expression de la sPLA2-IIA. Notre premier objectif sera donc de vérifier si le niveau de sPLA2-IIA est modulé par l’administration des antibiotiques. Nous vérifierons également l’effet bactéricide de la sPLA2-IIA sur différentes bactéries afin de confirmer les résultats de séquençage. Nos résultats permettront de mieux comprendre comment les interactions entre la sPLA2-IIA, la flore microbienne et le système immunitaire contribuent au développement de désordres immunitaires.

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Superviseur du corps professoral :

Éric Boilard

Étudiant :

Partenaire :

Université Nice Sophia Antipolis

Discipline :

Life Sciences

Secteur :

Education

Université :

Université Laval

Programme :

Globalink Research Award

Using the cannabis microbiome for sustainable production

Microbes in horticulture are typically something to avoid or eliminate, as pathogens are a significant problem in yield a crop quality. But microbes can also be beneficial, by helping plants access nutrients and preventing pathogen outbreaks. Rather than trying to eliminate all microbes, it may be better to manage naturally occurring, diverse microbial assemblages in the plant and within the production facility. The addition of specific beneficial microbes may also help improve crop performance and help transition facilities to organic production. To do this however, a comprehensive knowledge about the microbes associating with cannabis and its production is needed.

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Superviseur du corps professoral :

Miranda Hart

Étudiant :

Partenaire :

DOJA Cannabis Ltd

Discipline :

Life Sciences

Secteur :

Agriculture

Université :

The University of British Columbia - Okanagan

Programme :

Accelerate

Validity and Reliability of Ultrasonography for the Objective Assessment of Diaphragm Function in Healthy Adults

The diaphragm is the major inspiratory muscle in humans. Making accurate assessment of diaphragmatic function a key component of monitoring and assessing respiratory health. Presently, the gold-standard clinical assessment of diaphragmatic function involves measuring the pressure difference across the diaphragm using dual balloon-tipped catheters. While this technique is direct, accurate and reliable, it is also expensive, invasive and not suitable for all patient populations. Recently, the use of ultrasonography to measure muscle tissue stress and strain during contraction has emerged as a powerful and effective tool to non-invasively assess cardiac function. Similar techniques have been proposed and piloted in the assessment of diaphragm function, but have not been validated with current gold standards. The purpose of this study, therefore, is to introduce a novel method of evaluating the contractile properties of the human diaphragm in healthy, young adults. TO BE CONT’D

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Superviseur du corps professoral :

Christopher West

Étudiant :

Partenaire :

Brunel University of London

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology; Other

Université :

The University of British Columbia

Programme :

Globalink Research Award

Shorebird Habitat Use and Foraging Ecology on Bulls Island, South Carolina

My research focus is shorebird ecology and conservation. Shorebird populations are declining globally, likely as a result of environmental changes and the expansion of human development. These birds are particularly vulnerable to habitat loss or degradation at their coastal wintering sites where they refuel from migration and prepare for their next breeding season. I will conduct my field work on Bulls Island in South Carolina, an important wintering ground for several shorebird species. To better understand habitat use and to estimate abundance and distribution of shorebirds on Bulls Island, I will conduct regular surveys from January to the end of April. It is important to monitor this population in order to assess current and future pressures on these species. To determine food availability as a measure of habitat quality, I will take substrate samples at various sites on the island and identify and count invertebrate prey. Wintering sites with high density and diversity of invertebrates are extremely important for the well-being of shorebird populations. The data I collect on Bulls Island will provide information on the relationship between shorebird behaviour and habitat quality at this site. […]

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Superviseur du corps professoral :

Erica Nol

Étudiant :

Partenaire :

Clemson University

Discipline :

Life Sciences

Secteur :

Environmental Science and Technology; Life Sciences (not health); Natural Resources

Université :

Trent University

Programme :

Globalink Research Award

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