Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30156 projets achevés

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812
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673
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842
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8957
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96
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579
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Projets par catégorie

A new paradigm for the discovery of anti-cancer drugs based on tumour RNA disruption

While chemotherapy drugs are effective in combating tumour growth in cancer patients, many such drugs permit the development of drug-resistant tumours and progression of the disease. We have observed that several chemotherapy agents induce the degradation of tumour cell ribonucleic acid (RNA) in the laboratory and in cancer patients. We have further shown that this RNA degradation is associated with complete tumour destruction after-treatment. Our recently developed assay to quantify RNA degradation in tumour cells may thus prove to be a very sensitive, quantitative, high throughput, and preferred method for the discovery of anti-cancer drugs that will commit tumours to complete destruction. The study to be performed by the intern will assess this hypothesis in comparison to the current “gold standard” for anti-cancer drug discovery (the “clonogenic” assay).

Voir la description complète du projet
Superviseur du corps professoral :

Carita Lanner

Étudiant :

Partenaire :

RNA Diagnostics Inc

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology; Professional, scientific and technical services

Université :

Laurentian University

Programme :

Accelerate

Ecological and Cultural Restoration of an iconic Plant Food (Fritillaria camschatcensis) in the Squamish River Estuary, British Columbia

I am a member of the Squamish Nation and my research focuses on restoring an important traditional plant food into the Squamish estuary. The title of my research is “Ecological and Cultural Restoration of an iconic Plant Food (Fritillaria camschatcensis) in the Squamish River Estuary, British Columbia.” I will be working with Dr. Nancy Turner and Dr. Trevor Lantz as my co-supervisors at the University of Victoria to undertake this research as part of a larger research project led by Dr. Turner called “Bringing the Foods Home” that focuses on renewing traditional foods in Indigenous communities. My research will focus on conducting an ecological survey of the Squamish estuary to characterize successful riceroot habitat and then to construct an experimental garden where this plant can be tended to and used for educational purposes. I will incorporate community involvement throughout this research and emphasize the link between traditional foods and health.

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Superviseur du corps professoral :

Nancy Turner

Étudiant :

Partenaire :

Discipline :

Earth science

Secteur :

Public administration

Université :

University of Victoria

Programme :

Accelerate

Identification of early events involved in RNA disruption in order to improve its utility as a chemotherapy response and prognostic biomarker

It is not well known that the majority of breast cancer patients do not receive a survival benefit from chemotherapy. Yet, they experience many negative short- and long-term side effects from chemotherapy. This is also the case for other cancers. There is thus a clear, unmet need for a diagnostic tool that can reliably identify chemotherapy nonresponders, so that they can be moved quickly to potentially more beneficial treatments, while sparing the toxicities of the ineffective drugs. We have developed an effective tool (RDA) to assess chemotherapy response in cancer patients, based on the ability of chemotherapy drugs to induce the degradation of ribonucleic acid (RNA) in tumours. This project seeks to better understand the mechanisms by which chemotherapy drugs promote RNA degradation. By identifying earlier events that trigger RNA degradation, we expect to improve our ability to predict chemotherapy response in cancer patients, possibly much earlier after chemotherapy
administration.

Voir la description complète du projet
Superviseur du corps professoral :

Carita Lanner

Étudiant :

Partenaire :

RNA Diagnostics Inc

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology; Professional, scientific and technical services

Université :

Laurentian University

Programme :

Accelerate

Cross-sector partnerships for implementing sustainable community plans: comparison between a Canadian city and international communities to determine drivers for partners to remain in the partnerships

The project involves the identification of a Canadian community to be compared with Barcelona (Spain), Bristol (UK) and other two international communities, all experienced cities on sustainability with more than 100 partners including businesses, NGOs, academia and the public sector. The Canadian community must comply with certain criteria to make findings comparable with the international communities. The information to be collected is about the drivers for the partners to join
and remain in a partnership for sustainability, a key for policy makers and practitioners in the design of sustainability plans and partnerships for reaching sustainability goals. ICLEI Canada will benefit from this research by having access to information from four highly recognized communities and by comparing them to one of its members as a benchmark for the improvement of their sustainability initiatives. Furthermore, the findings will be generalizable information that will help improve their products and services.

Voir la description complète du projet
Superviseur du corps professoral :

Amelia Clarke

Étudiant :

Partenaire :

ICLEI Local Governments for Sustainability

Discipline :

Sociology

Secteur :

Professional, scientific and technical services; Public administration

Université :

University of Waterloo

Programme :

Accelerate

A Survey of Ergonomics Education Opportunities Available to Dental Hygienists in Ontario.

Dental hygienists (DH) are exposed to many potentially injurious physical demands, such as prolonged exposure to awkward neck, trunk, and shoulder postures. The prevalence of musculoskeletal disorders in this group is alarmingly high (62-93%). DH would benefit from ergonomics-specific workplace safety education, but it is unknown what sort of instruction, if any, is currently offered within the DH curriculum or for continuing education credit. Evaluation of existing educational opportunities will be conducted using a web-based survey of DH across Ontario. The surveys will also include questions regarding the mode of continuing education the DH would find most accessible (e.g. online or night courses, workshops, etc.). The results of the
survey will guide ergonomists at the Occupational Health Clinics for Ontario Workers Inc. in updating existing and/or creating new educational resources for registered DH and DH programs, in order to promote proactive injury prevention in this occupational group across the Province.

Voir la description complète du projet
Superviseur du corps professoral :

Nadia Azar

Étudiant :

Partenaire :

Occupational Health Clinics for Ontario Workers Inc

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology

Université :

University of Windsor

Programme :

Accelerate

Stock assessment in a changing world: quantifying the length of time series data for reliable stock assessments of Lake Whitefish in the Great Lakes

Lake Whitefish (Coregonus clupeaformis) are currently the subject of research to obtain Marine Stewardship Council certification for the fishery in Lake Erie. The declines of Lake Whitefish stocks in Lakes Huron, Erie and Ontario have drawn much concern from the fishing industry, regulators, and other stakeholders. Better estimates of the stock status are needed to understand the causes of this decline and to facilitate more sustainable management of these stocks. My project aims
to assess Lake Whitefish stock status by 1) selecting appropriate stock assessment models for Lake Whitefish from a literature review, 2) estimating the stock abundance by fitting selected models to time series data to determine the optimal length that minimizes effects of errors generated from surveys versus ecological processes, and 3) providing advice on future research priorities among improvement of survey techniques, determination of ecological mechanisms responsible for stock dynamics, or both.

Voir la description complète du projet
Superviseur du corps professoral :

Thomas Nudds

Étudiant :

Partenaire :

Ontario Commercial Fisheries Association

Discipline :

Life Sciences

Secteur :

Agriculture

Université :

University of Guelph

Programme :

Accelerate

Experimental Study on Vectorbloc Connection Used in Modular Construction

Modular construction has been gaining its popularity and momentum because it is a cheaper and faster way to build buildings and other structures. Vectorbloc Corp., located in Toronto has developed the concept of steel tubular modular construction using hollow structural steel (HSS) members. This modular construction will use various connectors and assemblies. The primary connector to be used in the HSS-based modular building construction is called Vectorbloc connector which is a cast-steel connector that facilitates the efficient design and construction of volumetric modular steel building structures. This research will undertake full-scale tests on Vectorbloc connections to be used in modular constriction. Various load combinations will be applied to simulate axial loading on the Vectorbloc connector. These tests will be undertaken in the structural engineering testing laboratory newly built at the University of Windsor and test data will be used to validate the concept modular construction developed by Vectorbloc Corp.

Voir la description complète du projet
Superviseur du corps professoral :

Sreekanta Das

Étudiant :

Partenaire :

VectorBloc Corp

Discipline :

Engineering

Secteur :

Construction and infrastructure

Université :

University of Windsor

Programme :

Accelerate

Profil, pratiques et comportements alimentaires d’usagers de Moisson Montréal

L’insécurité alimentaire touche une partie importante de la population montréalaise (16,2%) plaçant la ville au 2e rang des villes canadiennes en matière d’insécurité alimentaire. Afin de contribuer à l’allègement de cette situation préoccupante, Moisson Montréal (MM) offre des services de partage de denrées alimentaires et autres denrées de nécessité à la population montréalaise par l’entremise d’une multitude d’organismes qui se chargent de l’utilisation de ces denrées à bon escient. Dans un but d’optimisation des activités de MM et des organismes récipiendaires ainsi que la bonification des services offerts aux bénéficiaires primaires, soient les familles et individus montréalais, ce projet de recherche mené en partenariat entre le Département de nutrition de l’Université de Montréal et Moisson Montréal se propose d’étudier les pratiques courantes en
matière de sécurité alimentaire et d’identifier celles, parmi elles, qui contribuent à l’allègement et, éventuellement, à la résolution du problème d’insécurité alimentaire à Montréal.

Voir la description complète du projet
Superviseur du corps professoral :

Malek Batal

Étudiant :

Partenaire :

Moisson Montreal

Discipline :

Sociology

Secteur :

Health and Related Sciences & Technology

Université :

Université de Montréal

Programme :

Accelerate

Hollow Microneedle Manufacturing Process Development

Microneedles are hollow needle structures made out of metal, polymer, or silicon which can be manufactured at any height up to one millimetre, with arrays from one to hundred microneedles, depending on the required playload for delivery. Microneedles platform technology can be applied in medical, cosmetic, biotechnology, and industrial applications. The partner
organization has developed a low-cost process for manufacturing hollow microneedle arrays. The intent of this project is to improve and optimize the manufacturing process to increase microneedle uniformity and manufacturing repeatability. Different fabrication processes and process sequences for creating microneedle tip opening will be investigated to increase the robustness of the prototype manufacturing process. Also, the choice of sacrificial material will be optimized to improve the metal electroplating process and device removal from the mould. These improvements are necessary for finalizing the design of the prototype and creating a Minimum Viable Product for clinical trials testing.

Voir la description complète du projet
Superviseur du corps professoral :

Konrad Walus

Étudiant :

Partenaire :

Microdermics Inc

Discipline :

Engineering

Secteur :

Manufacturing

Université :

The University of British Columbia

Programme :

Accelerate

Dynamic forces on non-symmetrical elastic elements

The St. Lawrence River harbours a complex ecosystem whose physical properties vary from upstream to downstream. It includes lakes and freshwater reaches, a long estuary, and a gulf with marine features. The area is home to richly diverse habitats and an equally rich diversity of flora and fauna. It is a natural resource to be sustained and preserved. The attempt of SSL construction is to perform an in-water installation of precast elements. This is to avoid minimal intervention to Saint Lawrence ecosystem and life and economical cycle. This study facilitates the in-water construction and support sustainable road and infrastructure development by SSL construction.

Voir la description complète du projet
Superviseur du corps professoral :

Vincent Chu

Étudiant :

Partenaire :

Signature Sur Le Saint-Laurent Construction

Discipline :

Engineering

Secteur :

Construction and infrastructure

Université :

McGill University

Programme :

Accelerate

Évaluation de scénarios de restauration de la halde à stérile et du parc à rejets de la mine Canadian Malartic à l’aide d’essais sur le terrain

Les mines à ciel ouvert produisent des quantités importantes de rejets miniers. Selon la réglementation, les entreprises minières doivent restaurer les aires d’entreposage des rejets miniers à la fin des opérations, c’est-à-dire s’assurer que le site ne génère pas de contamination. Le site de la mine Canadian Malartic est particulier en raison de son envergure (plus d’un milliard de tonnes de rejets produits à la fin des opérations). Ainsi, la mine Canadian Malartic vise la réutilisation d’une partie des rejets produits sur place par la mine dans la restauration de ses aires d’entreposage. Le stage s’inscrit dans un vaste projet de recherche qui comprend la mise en place et le suivi de cellules expérimentales sur le site minier. Ces essais ont pour but de déterminer les méthodes de restauration optimales pour la mine Canadian Malartic, tout en favorisant la réutilisation des rejets inertes. La stagiaire bénéficiera d’une expérience pratique de mise en place de cellules expérimentales sur un site minier. Le stage permettra de définir une méthodologie de contrôle de qualité à appliquer lors de la mise en place d’essais de terrain simulant des scénarios de restauration faits avec des matériaux miniers.

Voir la description complète du projet
Superviseur du corps professoral :

Isabelle Demers

Étudiant :

Partenaire :

Mine Canadian Malartic

Discipline :

Engineering

Secteur :

Mining

Université :

Université du Québec en Abitibi-Témiscamingue

Programme :

Accelerate

Impact de la navigation en milieu lacustre sur la qualité de l’eau et le relargage de polluants

L’augmentation des sports nautiques utilisant des embarcations à moteurs est une préoccupation pour les citoyens, associations, municipalités soucieux de l’impact écologique sur les lacs. Il est difficile de trouver des solutions environnementales et durables satisfaisantes en termes de réglementation. Ce projet de recherche est donc défini afin de fournir un cadre scientifique dont le but est de : Développer des règlements qui seront proposés au gouvernement fédéral afin de mieux encadrer l’usage des embarcations sur les lacs. Le projet étudiera diverses d’embarcations motorisées afin d’élargir les connaissances sur l’impact de la navigation sur les lacs et notamment la remise en suspension des sédiments et l’érosion des berges. L’étude proposée a trois principaux objectifs : 1) définir l’impact de la profondeur des jets des systèmes de propulsion des embarcations susceptible de remettre en suspension les sédiments ; 2) définir la hauteur et l’énergie des vagues produites par les d’embarcations susceptibles d’éroder les berges ; et 3) étudier le relargage des nutriments et polluants par la remise en suspension des sédiments.

Voir la description complète du projet
Superviseur du corps professoral :

Rosa Galvez

Étudiant :

Partenaire :

Coalition pour la navigation responsable et durable

Discipline :

Engineering

Secteur :

Professional, scientific and technical services

Université :

Université Laval

Programme :

Accelerate

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