An antioxidant formulation to prevent DNA damage

Exposure to diagnostic imaging techniques such as computed tomography (CT) scan has been reported as a potential cause of DNA damage leading to cancer in patients as well as health care professionals. Coramed wishes to develop a unique antioxidant formula to avoid the above risk. With the aim of incorporating natural antioxidants present in apple in the formula, Coramed needs urgently to establish evidence of apple flavonoids’ efficacy in prevention of DNA double-strand break caused by carcinogenic factors. The specific objectives of the project are to assess whether the addition of apple flavonoids (AF4) and quercetin to the Coramed antioxidant formulation (AOX1) could contribute to the protection against DNA damage. The intern (a postdoctoral fellow) will examine carcinogen-induced DNA damage using a cell model system to assess test compounds. The expected result will become useful for the Coramed to optimize the antioxidant formula including apple flavonoids and/or quercetin and then to obtain required approvals for commercialization.

Faculty Supervisor:

Vasantha Rupasinghe;Graham Dellaire

Student:

Partner:

9165878 Canada Inc

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

Dalhousie University

Program: