Examining the Roles of Mouse Immune Cells in Liver Regeneration

The mammalian liver is known for its regenerative property, capable of fully restoring mass and function after injury. However, when this process is in disarray, chronic liver diseases occur, for which the current solution is liver transplantation. Transplantation remains an imperfect solution as the supply is limited and rejection can happen. Today, 25% of patients waiting for transplantation die before a liver becomes available. This study aims to describe a regenerating liver at the cellular level to explore the alternatives to liver transplantation. By removing part of the liver and observing how different cells change as the liver regrows, we will identify the key players in this process thereby offering therapeutic strategies in supplementing these cells to treat liver diseases.

Faculty Supervisor:

Gonzalo Sapisochin

Student:

Partner:

Industrial Biodevelopmental Laboratory

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: