Genetic susceptibility to renal cancer

Renal cell carcinoma (RCC), the most common type of kidney cancer, is characterized by heterogeneous tumor biology and clinical outcomes. Due to the indeterminate behavior of RCC and the absence of routine biomarkers, it is difficult to identify individuals at risk to develop RCC, and patients who are at high-risk of relapse. There are also unexplained large variations in incidence of RCC worldwide. Genetic factors play an important role in susceptibility to and progression of cancer. Identifying actionable genetic variants has greatly helped with the prevention and surveillance of some cancers, including breast cancer. Similarly, genetic analysis has potentials for identifying individuals who may be at risk for RCC, however our knowledge about genetic background of RCC is limited. We aim to interrogate known cancer susceptibility genes and examine patterns that contribute to susceptibility in RCC. This research study serves as a path toward methods of risk-assessment for RCC, its progression and therapy selection.

Faculty Supervisor:

Yasser Riazalhosseini

Student:

Partner:

RIKEN (Center for Integrative Medical Sciences)

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

McGill University

Program: