Improved Synthesis of [18F]-4-Fluorohomoleucine (FHL) for Imaging of Multiple Myeloma

Positron emission tomography (PET) imaging is an imaging technique used for the early detection of tumors and metastases, and plays an important role in diagnosis, staging, and treatment planning. PET imaging relies on radiotracers (molecules with a radioisotope attached) that selectively accumulate in tumors and can be detected by a PET scanner. Thus, the discovery of new radiotracers can enable improved imaging and diagnoses of cancer. We have discovered a radiotracer called 18F-FHL, which relies on the radioisotope fluorine-18 (18F), and have demonstrated its utility in imaging cancer in various preclinical models. Here, we plan to improve the production method for 18F-FHL such that it can be used globally and at lower doses. Additionally, we will develop a streamlined purification process that will enable translation to clinical studies.

Faculty Supervisor:

Robert Britton;Daniel Leznoff

Student:

Partner:

Centre for Probe Development and Commercialization

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services; Retail trade

University:

Simon Fraser University

Program: