Lowering Costs in Biotherapeutics: Raman Spectroscopy for Real-Time Antifoam Detection in Perfusion Bioreactors

This project aims to improve the production of monoclonal antibody (mAb) based medicines by developing a novel method for measuring antifoaming agents within perfusion bioreactors used to produce mAbs. Antifoams are necessary to keep bioreactors running smoothly, but they are also widely believed to contribute to reactor membrane fouling, which increases costs and severely limits how long these manufacturing systems can operate. During the placement, the intern will work with the host institution to develop and validate a Raman spectroscopybased method to measure antifoam concentrations in real time, then bring this method back to the home institution for use in ongoing perfusion bioreactor research. The project benefits the host institution by applying its advanced analytical expertise to a new and practical manufacturing challenge, while the home institution gains new analytical tools, trained personnel, and transferable methods that strengthen its continuous biomanufacturing research capacity. Together, this collaboration supports more efficient bioprocess development and contributes to long-term improvements in biologics manufacturing research.

Faculty Supervisor:

David Latulippe

Student:

Partner:

University College London

Discipline:

Engineering

Sector:

Education

University:

McMaster University

Program: