Mass spectrometry imaging of glucocorticoids in the mouse thymus

The project aims to better understand how stress hormones (i.e., glucocorticoids) are synthesized in the thymus, a key primary lymphoid organ of the immune system. Stress hormones are critical for proper thymic development and immune function. However, many details about how and where in the thymus stress hormones are produced remain unexplored. As part of the proposed project, the student will be visiting the University of Edinburgh to access state-of-the-art mass spectrometry (MS) imaging. MS imaginng is a revolutionary technique that permits regional analysis of stress hormones directly from organ tissue surfaces. No research institution in North America possesses MS imaging for glucocorticoid detection, and the host supervisor (Prof. Ruth Andrew) has the unique expertise required. This project will produce a “map” of stress hormone distribution and levels within the thymus using a mouse model. The student will fill critical gaps in knowledge in immune-endocrine crosstalk that can be applied to interventions and preventions in immune system disorders.

Faculty Supervisor:

Kiran Soma

Student:

Partner:

University of Edinburgh

Discipline:

Life Sciences

Sector:

Education

University:

The University of British Columbia

Program: