Neuroinflammation in Huntington’s Disease

Huntington’s disease (HD) is a genetic neurodegenerative disease characterized by cognitive, motor, and psychiatric disturbance ending in death 15 to 20 years after the onset of the first symptoms. The genetic predictability of HD makes it potentially the most tractable of the neurodegenerative diseases for early intervention, with the optimum time for the introduction of disease-modifying therapies being before the onset of symptoms. Despite discovering the underlying genetic mutation more than 20 years ago, treatment remains focused on symptomatic management. Given the devastating emotional costs of this disorder and the significant financial burden, these individuals impose upon society, developing a treatment regime for HD is a recognized priority. To treat a disease, it is necessary to understand the mechanisms behind the symptoms. So, in this project, we will investigate the role of inflammation in HD neuropathology.

Faculty Supervisor:

Sebastien Talbot

Student:

Partner:

Universidade Federal de Santa Catarina

Discipline:

Life Sciences

Sector:

Education

University:

Université de Montréal

Program: