Study of the permeability of dendrimers as vectors of active ingredients intended for topical applications

Three decades ago, science saw a major revolution in the nanomedicine field. The invention changed the dynamics of drug delivery and ever since, numerous studies have been done to help in delivering drugs with the aid of nanomedicines. Dendrimers are new generation of vectors used in skin drug delivery mostly because of their small size, molecular symmetry, and highly functional surface that could be modified. Dendrimers can modify drug release by enhancing drug dissolution, stability, drug release, targeting and pharmacokinetics of various drugs and could be tailored to penetrate the skin.
This project would be divided in 2 parts:
1- Synthesis and characterization of fluorescent dendrimers: realization of chemical coupling; manipulation of characterization by NMR, DSC, SEC, fluorometry; analysis and interpretation of results.
2- In vitro study of the permeability and biocompatibility of fluorescent vectors.

Faculty Supervisor:

Valerie Gaelle Roullin

Student:

Partner:

Miguel Hernández University of Elche

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Nanotechnology; Pharmaceuticals

University:

Université de Montréal

Program: