Supramolecular Hydrogels as new stimulable drug delivery systems

This project is based on the development of a new spatiotemporal release system for combination of active principle ingredients (API) under mechanical stimuli. The therapeutic schemes for some pathologies is based on the use of combined drugs to improve the efficiency or reduce the risk of resistance (cancer, infection treatments). Moreover, the use of hydrogels as drug delivery systems enables to reduce side effects due to a localized effect. Combining all these elements, the student will work on the formulation of stimulable supramolecular hydrogels. The molecules synthetized in our laboratory have the properties under high stress to go from a gel state to a liquid state. The formulation go back to its initial state (gel) when the stress is removed (just like ketchup). It’s very useful for hydrogel injection. In these news biomaterials, several API will be added to obtain combined therapies. TO BE CONT’D

Faculty Supervisor:

Chris Flinn

Student:

Partner:

Université de Bordeaux

Discipline:

Life Sciences

Sector:

University:

Memorial University of Newfoundland

Program:

Globalink Research Award