The effects of Bisphenol A and Bisphenol S on cross-talk between primary human adipocytes and primary human muscle cells

Bisphenol A (BPA), and its analog bisphenol S (BPS) are synthetic compounds commonly found in plastic products, and chronic exposure has been associated with adverse health outcomes such as the development of insulin resistance and type 2 diabetes (T2D). Low levels of these pollutants can transfer from polymers to food or water and can accumulate in adipose tissue due to lipophilicity. Furthermore, adipocytes release hormones, such as adiponectin, that enable cross-talk with skeletal muscle. Therefore, we will investigate the effects of BPA and BPS on adipocyte metabolism and cross-talk with the skeletal muscle. Specifically, we will look at lipid and glucose metabolism primary human adipocytes treated with BPA and BPS. In addition, primary skeletal muscle cells will be exposed to the conditioned media of adipocytes treated with these pollutants, in order to investigate cross-talk between these tissues. TO BE CONT’D

Faculty Supervisor:

Celine Aguer

Student:

Partner:

Uppsala Universitet

Discipline:

Life Sciences

Sector:

Education

University:

University of Ottawa

Program: