Understanding Stress Signaling in Childhood Cancers to Elucidate New Strategies for Therapy in Metastatic Childhood Cancers

The Sorensen laboratory-based Childhood Cancer Research Program is specifically focused

on elucidating the genetic and biological determinants of the metastatic process in childhood

cancer. Metastatic disease remains the single most dominant driver of adverse outcome in

most childhood cancers, particularly in childhood sarcomas. Research in the program is

dedicated to uncovering the mysteries of metastatic childhood cancer. This distinguishes the

Childhood Cancer Research Program from other international efforts, which are typically

focused on analysis of primary tumours. There are two basic strategies in the program for

studying metastatic disease in childhood cancers. The first is to focus on cell stress signaling.

Emerging evidence indicates that adaptation to prototypical forms of cell stress plays a major

role in tumor cell selection and metastasis. The second strategy is to perform next-generation

sequencing of childhood tumours in triplicate specimens (samples of the primary and

metastatic tumours and matching normal tissues). By sequencing both primary and

metastatic tumours from the same patients, and comparing them to….TOBECONTINUED

Faculty Supervisor:

Poul Sorensen

Student:

Partner:

Team Finn Foundation;BC Cancer Agency

Discipline:

Life Sciences

Sector:

Other services (except public administration)

University:

The University of British Columbia

Program:

Accelerate

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