Using hyperpolarized 13P MRI measure in vivo pH of the placenta

Placental dysfunction is the leading cause of stillbirth, and assessment of fetoplacental health in utero is limited. Our goal is to use MRI to gain functional information of the placenta, specifically to measure pH as a critical indicator of placental health. Current methods of this use 13P MRS but are challenged by low signal-to-noise ratio (SNR). We propose using hyperpolarized 31P phosphates to significantly boost signal (10 000 fold) and are biologically safe and therefore clinically relevant. This study will demonstrate the first instance of hyperpolarized 31P pH imaging in vivo. pH data obtained using this method would compliment metabolic information we are able to observe using hyperpolarized C13 compounds like pyruvate. pH is an indicator of fetal health and this technique could provide information relevant for clinical decisions on interventions in the event of problematic pregnancies. TO BE CONT’D

Faculty Supervisor:

Charles McKenzie

Student:

Partner:

The Hebrew University of Jerusalem

Discipline:

Life Sciences

Sector:

University:

Western University

Program:

Globalink Research Award