Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

29670 projets achevés

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Projets par catégorie

Process intensification for production of rVSV

To prevent diseases such as coronavirus disease 2019 (COVID-19) and Ebola virus disease vaccines are the most effective tool. For this, the promising viral vector recombinant vesicular stomatitis virus (rVSV) is applied as production platform. Using suspension HEK293 cells, rVSV-based vectors are currently only produced in batch mode. However, the establishment of perfusion cultivations at high cell concentration would clearly reduce the footprint in plants and increase flexibility in virus vector manufacturing. Thus, we seek to intensify the production of rVSV-based vectors by first obtaining higher concentrations of suspension HEK293 cells in perfusion mode and second applying monitoring and control strategies to achieve maximum infectious virus yields at reduced medium consumption. For this, one bioreactor run in batch mode and two production runs in perfusion mode are planned. The first perfusion cultivation will comprise the use of a cell retention unit coupled to a hollow fiber membrane. For the second perfusion culture, a membrane allowing for continuous virus harvesting and storage of infectious virions will be incorporated.

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Superviseur du corps professoral :

Amine Kamen

Étudiant :

Partenaire :

Institut Max Planck pour la dynamique des systèmes techniques complexes

Discipline :

Génie

Secteur :

Biotechnology; Global Health; Pharmaceuticals

Université :

Université McGill

Programme :

Bourse de recherche Globalink

AI for catalyst discovery

In this project, we will develop innovative AI tools to speed up the process of catalyst discovery, in particular in the domain of renewable energy. Specific catalysts are essential to applications such as the efficient synthesis of solar fuels and fertilizer. However, many known catalysts are suboptimal in their efficacy or require scarce elements. Currently, catalyst development is held back by the computational cost of the quantum chemistry simulations used to guide experimentation, as well as the very high-dimensional search space of potential catalysts. AI offers the opportunity to significantly accelerate the discovery of catalysts, both by performing fast approximate simulations to assess the efficacy of individual catalysts and by intelligently searching for optima in the space of candidate materials. Specifically, we will build AI algorithms that operate on the graphical structure of chemical compounds, incorporating chemistry-related constraints and integrating into larger AI-based materials discovery pipelines.

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Superviseur du corps professoral :

Yoshua Bengio

Étudiant :

Partenaire :

Inria Saclay - Centre de recherche Île-de-France

Discipline :

Informatique

Secteur :

Artificial Intelligence; Green/Alternative Energy; Achieving Net Zero; Quantum Science

Université :

Université de Montréal

Programme :

Bourse de recherche Globalink

Assessing memantine induced mitophagy in a neurodegenerative model of Drosophila

A consequence of aging is the increased risk of neurodegenerative disease. In the pathogenesis of neurodegenerative diseases is the production of misfolded proteins which can clump together and interfere with normal cellular function. Mitochondria are highly important as they produce energy necessary for cell survival as well as regulate the controlled cell death process of apoptosis. Misfolded proteins are able to interact with mitochondria in such a way that dysregulates energy production, putting the cell at risk of undergoing cell death if not dealt with, thereby contributing to the decline of neurons seen in neurodegenerative disease. This project aims to investigate the induction of mitophagy, a pathway through which depolarised mitochondria are removed, in an in vivo model of Drosophila melangoster (common fruit fly). In so doing, we aim to better understand the effects of systemic mitophagy induction in a model of neurodegenerative disease.

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Superviseur du corps professoral :

Angus McQuibban

Étudiant :

Partenaire :

Université de Stellenbosch

Discipline :

Sciences de la vie

Secteur :

Life Sciences (not health); Health and Related Sciences & Technology; Global Health

Université :

Université de Toronto

Programme :

Bourse de recherche Globalink

Shoulder Rotation of Pedestrians passing a Bottleneck

Understanding pedestrian dynamics is crucial to the design of pedestrian facilities. Although pedestrian flows are part of everyday life, many basic characteristics of pedestrian dynamics cannot yet be described in detail.
The aim of the PhD project is to study the upper body rotation of pedestrians when crossing a narrow passage (bottleneck). Since the movement pattern of individuals differs significantly in individual movement, small groups, and crowds, correlations and transitions from free movement of an individual to restricted movement in crowds during traversal will be investigated.
It is expected that the analysis of the physical parameters is subject to the influence of social interaction. Furthermore, it is expected that, as a consequence, parameters such as the timing of deceleration or motivation change the motion sequence and thus the shoulder rotation in the bottleneck. The host supervisor, Dr. Max Kinateder, has been conducting research on human visual perception for a long time. Among other things, how behaviour in emergency situations is controlled by the social and architectural environment. Dr. Kinateder’s expertise provides the opportunity to extend the analysis of physical parameters to include social aspects and those of perception, thus laying the foundation for new model ideas.

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Superviseur du corps professoral :

Dr. Max Kinateder

Étudiant :

Partenaire :

Forschungszentrum Jülich

Discipline :

Génie

Secteur :

Information and Communications Technology; Transportation (excluding aerospace); Advanced Computing

Université :

Université Carleton

Programme :

Bourse de recherche Globalink

New directions for old aluminum: Innovating aluminum recycling through novel processes and materials

Demand for aluminum alloys is increasing rapidly, facilitation of electric vehicles being but one example. A consequence is increasing scrap supply; a positive as aluminum is highly recyclable with it consuming a fraction of resources compared to using primary aluminum. There is a growing concern, however, as high-performance alloys are compositionally tuned to maximize performance. Separation of similar but distinct alloys in a scrap yard is infeasible leading to a growing fraction of the scrap supply that can only be down-cycled. With scrap supply outstripping demand new recycling and reuse solutions are required. This proposal builds upon existing collaborations between UBC and MPIE, focusing on using advanced characterization techniques (at MPIE) to better understand materials, processed at UBC, that 1) have non-traditional alloy chemistries based on scrap compositions and 2) are fabricated by combining local scrap recovery and additive manufacturing.

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Superviseur du corps professoral :

Chad Sinclair

Étudiant :

Partenaire :

Max-Planck-Institut für Eisenforschung GmbH

Discipline :

Génie

Secteur :

Achieving Net Zero; Advanced Manufacturing; Sustainability & the Environment

Université :

L’Université de la Colombie-Britannique

Programme :

Bourse de recherche Globalink

Mutual avoidance between young and older adults when passing through an aperture

La capacité de percevoir le mouvement d’une personne approchant et d’effectuer des ajustements appropriés pour éviter les collisions est un élément essentiel de la locomotion sécuritaire dans l’environnement. Le projet proposé étudiera les comportements d’évitement des collisions chez les jeunes et les aînés avec un jeune adulte approchant afin de comprendre l’information visuelle utilisée pour accomplir la tâche. Le projet de recherche proposé fera en sorte que deux individus s’approchent d’une porte ouverte de côtés opposés et passent sans entrer en collision. Les déplacements des deux individus seront suivis à mesure qu’ils approchent et passent dans l’embrasure de la porte. Le projet déterminera si les individus utilisent des informations optiques, telles que le délai de contact (TTC), pour déterminer qui passera la porte en premier et éviter une collision avec l’autre. TTC est le temps restant avant que chaque individu atteigne la porte et, s’il est utilisé, il déterminera non seulement l’ordre d’arrivée, mais préserve aussi cet ordre de traversée. On croit que les jeunes adultes seront à l’écoute de cette information optique et l’utiliseront pour guider leurs actions, alors que les adultes plus âgés ne l’utiliseront peut-être pas.

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Superviseur du corps professoral :

Michael Cinelli

Étudiant :

Partenaire :

Université de Haute Bretagne Rennes 2

Discipline :

Sciences de la vie

Secteur :

Éducation

Université :

Université Wilfrid-Laurier

Programme :

Bourse de recherche Globalink

Feasibility Study of an IoT-based Real-time Safety Alerting System for Working at Heights in Construction Sites

In the proposed project, we will investigate a solution for increasing the safety of construction workers at heights using an intelligent sensor-based system. A real-time monitoring system will be developed for alerting workers who are getting close to hazardous conditions and areas. The objective is to lower the chance of accidents by enhancing supervision of workers for their safety based on regulations and working practices in a construction site. This is done by collecting the locations of workers along with equipment, tools, and machines, processing the information using cloud platforms, and making notifications when required. The project has three main components including (1) Hardware devices to be carried by users, (2) An IoT cloud platform, and (3) Various firmware modules for localization and position tracking.

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Superviseur du corps professoral :

Mehrdad Moallem

Étudiant :

Partenaire :

1252258 B.C. LTD.

Discipline :

Génie

Secteur :

Construction et infrastructures

Université :

Université Simon Fraser

Programme :

Accélération

Applications of AI in the development of public health solutions

This project will focus on the research areas of smart device monitoring and the analysis of complex medical data in public health. Through the use of artificial intelligence, researchers will develop solutions that exploit large-scale sensor data, address significant challenges caused by global threats by, for example, setting early heat alerts for extreme heat waves. These efforts will support older adults to live independently in smart home environments while maintaining a good quality of life.

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Superviseur du corps professoral :

Plinio Pelegrini Morita

Étudiant :

Partenaire :

Université de Strathclyde

Discipline :

Sciences de la vie

Secteur :

Sciences de la santé et technologies connexes; Intelligence artificielle; Technologie

Université :

Université de Waterloo

Programme :

Bourse de recherche Globalink

Characterization of stem cell-derived human dopaminergic neuron subtypes

The goals of this proposal are to develop methods to identify cell subgroups in dopaminergic (DA) neuron cultures obtained by differentiation of human pluripotent stem cells (hPSC), and to exploit this information to improve existing DA neuron differentiation protocols. To realize these goals, we will leverage expertise at STEMCELL Technologies in hPSC differentiation and Simon Fraser University (SFU) in high content screening and laboratory automation. In four specific aims we will; (1) automate DA neuron differentiation from induced hPSCs (iPSCs), (2) identify known DA neuron subgroups in these cultures using established antibody markers, and (3) identify morphological features of cellular organelles to facilitate identification of these subgroups using an automated cell profiling approach. Finally we will, (4) use these novel morphological features to screen a compound library of known bioactive molecules for those that increase the specificity of DA neuron differentiation to these subtypes

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Superviseur du corps professoral :

David Vocadlo;Dr. Lisa Julian

Étudiant :

Partenaire :

STEMCELL Technologies Canada Inc

Discipline :

Sciences de la vie

Secteur :

Sciences de la santé et technologies connexes; Fabrication; L’exploitation minière; Services professionnels, scientifiques et techniques

Université :

Université Simon Fraser

Programme :

Accélération

Unraveling the cells and genes uniquely contributing to doxorubicin-induced cardiotoxicity

Cancer is a devastating disease known to be treated with chemicals causing severe side effects in the advanced stages of the disease. Among these chemicals are a group of antibiotics, called anthracyclines, used to treat a variety of cancers, including breast cancer (BC). Doxorubicin, one of the preferred anthracyclines used in BC treatment, is particularly toxic to cancer cells, but also healthy tissue, leading to multi-organ damage, including damage to the heart. A new technology, called single-cell RNA sequencing (scRNA-seq), can determine which cells and genes in the heart contribute the most to the damage seen in the heart muscle following doxorubicin treatment, potentially leading to the identification of solutions. Using this technique, combined with advanced computer programs, the student aims to study doxorubicin-induced heart damage in a previously studied tumor-bearing mouse model. Herein, heart tissue will be processed and scRNA-seq performed, before analyzing the data and reporting the findings.

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Superviseur du corps professoral :

Britt Drögemöller;Galen Wright

Étudiant :

Partenaire :

Université de Stellenbosch

Discipline :

Sciences de la vie

Secteur :

Sciences de la santé et technologies connexes; Pharmaceutique; Technologie

Université :

Université du Manitoba

Programme :

Bourse de recherche Globalink

FeatTS-Detect : Features-Driven Time Series Anomaly Detection

With the rapid growth of sensors in Cyber-Physical Systems such as clinical data, industrial systems and data centres, there is an increasing need to monitor these devices to secure them against anomalies. This is particularly the case for streaming clinical data. Indeed, the timeliness revelation of anomalies in these data can save the patient’s life.
Time series anomaly detection has been a perennially important topic in data science, but in recent years there has been an explosion of interest in this topic.
The main objective of the project is to implement a system that permits to discover anomaly points and the anomaly subsequence of points in the time series data through a system that evaluates an anomaly considering a set of features extracted among the time series. The features have obtained good performance for clustering of time series. Therefore, our idea is to extend this technique for detecting anomalies.

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Superviseur du corps professoral :

Raymond Ng

Étudiant :

Partenaire :

Université Claude Bernard Lyon 1

Discipline :

Informatique

Secteur :

Éducation

Université :

L’Université de la Colombie-Britannique

Programme :

Bourse de recherche Globalink

Mass spectrometry imaging of glucocorticoids in the mouse thymus

The project aims to better understand how stress hormones (i.e., glucocorticoids) are synthesized in the thymus, a key primary lymphoid organ of the immune system. Stress hormones are critical for proper thymic development and immune function. However, many details about how and where in the thymus stress hormones are produced remain unexplored. As part of the proposed project, the student will be visiting the University of Edinburgh to access state-of-the-art mass spectrometry (MS) imaging. MS imaginng is a revolutionary technique that permits regional analysis of stress hormones directly from organ tissue surfaces. No research institution in North America possesses MS imaging for glucocorticoid detection, and the host supervisor (Prof. Ruth Andrew) has the unique expertise required. This project will produce a “map” of stress hormone distribution and levels within the thymus using a mouse model. The student will fill critical gaps in knowledge in immune-endocrine crosstalk that can be applied to interventions and preventions in immune system disorders.

Voir la description complète du projet
Superviseur du corps professoral :

Kiran Soma

Étudiant :

Partenaire :

University of Edinburgh

Discipline :

Sciences de la vie

Secteur :

Éducation

Université :

L’Université de la Colombie-Britannique

Programme :

Bourse de recherche Globalink

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