Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

29 670 projets achevés

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4990
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801
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663
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825
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8841
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9197
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95
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568
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Projets par catégorie

A fully customized image sensor for fluorescence imaging in biomedicine

Customized image sensors will be designed by EnviroSen specifically for advanced microscopes used in biomedical imaging. The goal is to develop image sensors with improved efficiency, image resolution and speed compared to existing technologies for novel microscopes for fluorescence lifetime imaging. The McMaster Biophotonics group has recently developed a novel microscope that is capable of detecting fluorescence lifetimes of biological samples with 400 times improvement in image acquisition speed. Although the commercially available image sensors are very advanced, they are still limited when applied to biomedical imaging applications. Thus, the McMaster Biophotonics team and EnviroSen’s technical staff will work closely to develop novel, fully customized image sensors that will overcome many of the technical challenges of biomedical imaging. Once developed, the potential applications of customized image sensors for advanced microscopy will open a new market for EnviroSen and allow McMaster’s Biophotonics team to explore other opportunities in this area.

Voir la description complète du projet
Superviseur du corps professoral :

Qiyin Fang

Étudiant :

Partenaire :

EnviroSen Inc;McMaster University

Discipline :

Engineering

Secteur :

Professional, scientific and technical services

Université :

McMaster University

Programme :

Elevate

Brainwave technology and health status quantification in dementia

Dementia involves significant memory loss and represents a major public health threat. Brainwave technologies can be used to monitor brain changes in the process of dementia. The proposed study is to apply the latest research advancement of brainwave technologies, called NeuroCatch. A hundred older adult participants with dementia and with cognitively normal aging will have multiple brainwave tests using NeuroCatch, at 0, 3, 6 and 12 months after enrolling into the study. Changes in the brainwave over time will be examined for individuals, compared between subject groups, and related with health assessment data. Findings of the study will help understand the neural basis of dementia and the relations of brain health with general health.

Voir la description complète du projet
Superviseur du corps professoral :

Ryan D’Arcy;Xiaowei Song

Étudiant :

Partenaire :

Lark Group;Pharmx Rexall Drug Stores Ltd

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology

Université :

Simon Fraser University

Programme :

Accelerate

Caractérisation de la diversité et de la phénologie des punaises Pentatomidae dans la culture du pois au Québec dans le but de développer une technique de dépistage fiable

Depuis les dernières années, les punaises de la famille des Pentatomidae posent de plus en plus de problèmes dans la culture du pois au Québec. Bien que la présence de ces dernières sur les plants ne provoque pas de pertes de rendement significatives, elles contaminent toutefois les récoltes. Leur ressemblance au pois, quant à la taille et à la couleur, rend l’opération de triage optique très difficile. La faible disponibilité d’insecticides homologués et efficaces pour contrôler ces punaises ont forcé le secteur à se tourner vers un insecticide à large spectre très nocif. Considérant l’augmentation des populations de punaises et l’arrivée récente d’une nouvelle espèce, soit la punaise marbrée, une bonne connaissance de leur biologie et des méthodes de dépistage est nécessaires pour envisager un programme de lutte intégrée. Le projet propose donc de documenter le cycle biologique des Pentatomidae dans la culture du pois et de proposer une stratégie de dépistage efficace contre cet ennemi. Ces connaissances permettront ainsi de mieux cibler les interventions phytosanitaires afin de minimiser l’utilisation des insecticides en milieu agricole.

Voir la description complète du projet
Superviseur du corps professoral :

Éric Lucas

Étudiant :

Partenaire :

CÉROM

Discipline :

Life Sciences

Secteur :

Agriculture and Food; Environmental Science and Technology

Université :

Université du Québec à Montréal

Programme :

Accelerate

Study the effect of magnetic liner on ball milling efficiency utilizing DEM modelling

HMR-Canada has introduced magnetic liners for grinding mills that will improve the mill performance and efficiency. Mill liners have two main functions. First they protect the mill shell from wear and deliver energy to the material by lifting the material in a trajectory that creates the energy needed to break the rocks.
Magnetic liners in specific add other functions to the liners. They attract scats and magnetic minerals that form a renewable protective layer, which would increase life span of liners and shell, easier and faster to install. Magnetic liners have been introduced before, but their design and shape were never optimised.
In this project the effect of the magnetic liner profile, the shape of the layer formed by the scats and magnetic minerals as well as the mill speed, on the charge trajectory, force distribution and energy spectra will be studied. The tool that will be used for this study is Discrete Element Modeling.

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Superviseur du corps professoral :

Bern Klein

Étudiant :

Partenaire :

HMR Technology Canada Ltd

Discipline :

Engineering

Secteur :

Mining

Université :

The University of British Columbia

Programme :

Accelerate

Feature extraction using 3D data acquired with a mobile scanning system designed for underground mining

The uGPS Rapid Mapper™ is a laser system mounted on a mining vehicle which acquires 3D images of tunnels in underground mines. Currently, engineers use the images for mine design and operations. This research project will create two new applications for the images acquired by the system: mapping of the geology of the tunnel walls (identifying different rock types, minerals veins and fractures) and making a tally of man-made objects (such as rock bolts, pipes and ventilation tubes). Access to geological data derived automatically from images will allow mining geologists to optimize their efforts and devote strategically their attention to the most promising areas. The inventory of man-made objects will assist in planning the development of the mine. Progress made during the project will help Peck Tech to expand the range of applicability of the uGPS Rapid Mapper™.

Voir la description complète du projet
Superviseur du corps professoral :

Claire Samson

Étudiant :

Partenaire :

Peck Tech

Discipline :

Earth science

Secteur :

Mining; Technology; Natural Resources

Université :

Carleton University

Programme :

Accelerate

Computational Approaches for Characterizing Non-canonical Tandem Mass Spectra

Extensive research has been conducted for the computational analysis of mass spectrometry based proteomics data, however most of the traditional computational approaches take the assumption that the acquired spectra are generated from the fragmentation of a single precursor and the peptide is simply a linear sequence of amino acid residues. This ubiquitous assumption is impeding the utility of those computational approaches, especially when handling those non-canonical tandem mass spectra. In this project, we aim to develop new computational approaches for the interpretation of two types of non-canonical mass spectra, the mixture tandem mass spectra coming from the concurrent fragmentation of multiple precursors in one sequencing attempt, and the tandem mass spectra resulting from the sequencing of disulfide linkage structures. The software tools or integrated software modules developed in this project will potentially enhance the applications of the software packages and expand the commercial services provided by the partnering company.

Voir la description complète du projet
Superviseur du corps professoral :

Kaizhong Zhang

Étudiant :

Partenaire :

Bioinformatics Solutions Inc;Western University

Discipline :

Computer science

Secteur :

Information and cultural industries; Professional, scientific and technical services

Université :

Western University

Programme :

Elevate

Improving signal processing in hearing aids to support music and emotional speech – Year 2

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing aids restore the intelligibility but not the emotional content of speech, which is carried by acoustic cues that are similar to salient dimensions of music. This project aims to refine hearing aid processing for music and to assess whether signal processing can clarify the emotional content of speech without compromising intelligibility. The partner organization will benefit from the advancement of hearing aid technology to better support hearing in everyday life. In particular, these advancements may lead more people with hearing impairment to adopt hearing aids and result in greater adherence to hearing aid use.

Voir la description complète du projet
Superviseur du corps professoral :

Frank Russo

Étudiant :

Partenaire :

Unitron Hearing;Toronto Metropolitan University

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology

Université :

Toronto Metropolitan University

Programme :

Elevate

Improving signal processing in hearing aids to support music and emotional speech

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing aids restore the intelligibility but not the emotional content of speech, which is carried by acoustic cues that are similar to salient dimensions of music. This project aims to refine hearing aid processing for music and to assess whether signal processing can clarify the emotional content of speech without compromising intelligibility. The partner organization will benefit from the advancement of hearing aid technology to better support hearing in everyday life. In particular, these advancements may lead more people with hearing impairment to adopt hearing aids and result in greater adherence to hearing aid use.

Voir la description complète du projet
Superviseur du corps professoral :

Frank Russo

Étudiant :

Partenaire :

Unitron Hearing;Toronto Metropolitan University

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology

Université :

Toronto Metropolitan University

Programme :

Elevate

Towards the development of a Bayesian prognostic tool of air pollution in Ontario

Air pollution is a major concern in urban centers because not only does affect vulnerable populations, but also impacts the quality of life for urban dwellers. With the new implementation of the Air Quality Health Index (AQHI) by the Ontario Ministry of the Environment and Climate Change to replace the existing Ontario Air Quality Index (AQI), there is an emerging need to forecast future environmental impacts on air quality and assess the achievability of the newly-adopted index. This research will develop a risk-assessment methodological framework to project the trends of AQHI’s pollutant concentrations due to changes in atmospheric conditions resulting from climate change in Ontario. We will use a combination of Global Climate Models (GCMs) and Bayesian inference techniques to provide a novel risk-assessment tool that can effectively support policy analysis by the Provincial and Federal government to combat climate change.

Voir la description complète du projet
Superviseur du corps professoral :

Willam Gough

Étudiant :

Partenaire :

AEML Associates Ltd;University of Toronto Scarborough

Discipline :

Physics

Secteur :

Professional, scientific and technical services

Université :

University of Toronto Scarborough

Programme :

Elevate

Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy – Year 2

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation. Partner organization will benefit from our extensive knowledge and expertise in researching hypoxia as the laboratory of Dr. Wouters is a world renowned expert in the field. I have gained a lot of experience in development and analysis of 3D cellular systems during my PhD research that concentrated in stem cell biology. Overall, this fruitful collaboration will lead to development of new line of therapeutics that could help save lives of hundreds of thousands of suffering cancer patients worldwide.

Voir la description complète du projet
Superviseur du corps professoral :

Brad Garry Wouters

Étudiant :

Partenaire :

Northern Biologics Inc;University of Toronto

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation. Partner organization will benefit from our extensive knowledge and expertise in researching hypoxia as the laboratory of Dr. Wouters is a world renowned expert in the field. I have gained a lot of experience in development and analysis of 3D cellular systems during my PhD research that concentrated in stem cell biology. Overall, this fruitful collaboration will lead to development of new line of therapeutics that could help save lives of hundreds of thousands of suffering cancer patients worldwide.

Voir la description complète du projet
Superviseur du corps professoral :

Brad Garry Wouters

Étudiant :

Partenaire :

Northern Biologics Inc;University of Toronto

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Development of specific inhibitors and activators to assess the role of human Ephrin Receptors in health and disease

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of Eph receptors are extremely complex, and developing an effective therapeutic intervention for a particular disease requires a comprehensive understanding of Eph function. The goal of this project is to generate a collection of synthetic antibody molecules that block and activate every Eph receptor. This toolkit of antibody reagents will allow researchers to identify the best approach for targeting Eph receptors individually or in combination to counteract a particular disease state. This collection of Eph-modulating antibody reagents will expand the existing antibody portfolio of the Centre for the Commercialization of Antibodies and Biologics (CCAB).

Voir la description complète du projet
Superviseur du corps professoral :

Jason Moffat

Étudiant :

Partenaire :

Centre for the Commercialization of Antibodies and Biologics;University of Toronto

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

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