Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30 508 projets complétés

2882
AB
5105
C.-B.
825
MB
681
NL
860
SK
9051
ON
9491
QC
97
PE
586
NB
1141
NS

Projets par catégorie

Impact of microparticles in cancer progression – Year two

Blood platelets are the principal source of cells known to shed small extracellular vesicles which package biologically active molecules. We have recently identified a new type of these vesicles (called microparticles/MPs) that contain mitochondria, which represent the energy producing motors for living cells. We have also discovered that MPs preferentially bind and internalize into leukemia cells to transfer their contents. As a result, recipient cancer cells gain energy producing capacity, which leads to increased cancer processes. Our objective is to characterize the mechanisms of MP interaction and sourcing of modulators leading to cancer progression. The elucidation of these novel mechanisms are essential for the development of specific compounds to block MP-cancer cell interactions. We believe that the mechanistic blockage of MP internalization will deprive cancer cells of vital resources for disease progression.
The Atlantic Cancer Research Institute/ACRI has developed a proprietary technology to capture MPs. Through our fruitful collaborations and use of this technology, we will elucidate MP targeting and binding of cancer cells for the development of new anticancer strategies. This research could bring significant economic benefits to our health care systems and provide the ACRI with business opportunities with potential partners invested in the treatment of blood cancers.

Voir la description complète du projet
Superviseur du corps professoral :

Gilles Robichaud

Étudiant :

Partenaire :

Atlantic Cancer Research Institute

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

Université de Moncton

Programme :

Elevate

Signalling Bodies as Resistant: Coded Queerness in Visual Culture

Through historical research, I examine the role of queer history to demonstrate how, and in what ways, oppression evolves into resistance. Focusing on visual culture, such as photographs, home video’s and films, as well as ephemera, letters and personal papers, the goal is to shed light on the dark corners of queer history. By illuminating historical pain and trauma, the intention is to reveal the resilience of previous generations, and where negative affects inform locations of recuperation. The need for such research is to provide future generations strategies of survival; where legacies of inequity can be recouped and systemically changed. Visual culture and personal papers of everyday LGBTQ2+ communities disclose the complexity of simple lives and provide salient, real world knowledge of those who came before us.

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Superviseur du corps professoral :

Janine Marchessault

Étudiant :

Partenaire :

The ArQuives

Discipline :

Sociology

Secteur :

Information and cultural industries

Université :

York University

Programme :

Accelerate

Impact of microparticles in cancer progression

Blood platelets are the principal source of cells known to shed small extracellular vesicles which package biologically active molecules. We have recently identified a new type of these vesicles (called microparticles/MPs) that contain mitochondria, which represent the energy producing motors for living cells. We have also discovered that MPs preferentially bind and internalize into leukemia cells to transfer their contents. As a result, recipient cancer cells gain energy producing capacity, which leads to increased cancer processes. Our objective is to characterize the mechanisms of MP interaction and sourcing of modulators leading to cancer progression. The elucidation of these novel mechanisms are essential for the development of specific compounds to block MP-cancer cell interactions. We believe that the mechanistic blockage of MP internalization will deprive cancer cells of vital resources for disease progression.
The Atlantic Cancer Research Institute/ACRI has developed a proprietary technology to capture MPs. Through our fruitful collaborations and use of this technology, we will elucidate MP targeting and binding of cancer cells for the development of new anticancer strategies. This research could bring significant economic benefits to our health care systems and provide the ACRI with business opportunities with potential partners invested in the treatment of blood cancers.

Voir la description complète du projet
Superviseur du corps professoral :

Gilles Robichaud

Étudiant :

Partenaire :

Atlantic Cancer Research Institute

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

Université de Moncton

Programme :

Elevate

Understanding the gaps in the adoption of animal care practices in Canada – Year two

Welfare issues such as lameness and body injuries (LBI) negatively impact health, productivity, and longevity of dairy cows. Despite research, regulatory and outreach efforts, the current prevalence of LBI is high in Canada and shows little evidence of improvement. The proposed study will use an integrated, structured approach to identify gaps influencing the adoption of on-farm practices for control of LBI from a multi-stakeholder perspective. Our methodology comprises 4 steps, each providing groundwork for the following: 1) Knowledge Synthesis will provide insights into Canada’s current situation of LBI and evidence of change throughout time; 2) Questionnaire administered to industry stakeholders (producers, advisors, milk processors, policy-makers, consumers) will investigate perceptions, needs and actions towards LBI; 3) Focus Groups will provide insights into stakeholders’ perceived role and barriers in adopting changes to improve LBI; and 4) knowledge gathered in steps 1-3 will create a platform to develop a plan for Knowledge Translation and Transfer (KTT) to support future extension efforts. Our study will be the first to engage a wide variety of dairy industry stakeholders nationwide to explore factors impacting their perceptions towards LBI and towards change. The outcome will be used to tailor KTT tools applicable to dairy farmers throughout Canada.

Voir la description complète du projet
Superviseur du corps professoral :

Daniel Weary

Étudiant :

Partenaire :

Lactanet (QC)

Discipline :

Life Sciences

Secteur :

Agriculture

Université :

The University of British Columbia

Programme :

Elevate

Understanding the gaps in the adoption of animal care practices in Canada

Welfare issues such as lameness and body injuries (LBI) negatively impact health, productivity, and longevity of dairy cows. Despite research, regulatory and outreach efforts, the current prevalence of LBI is high in Canada and shows little evidence of improvement. The proposed study will use an integrated, structured approach to identify gaps influencing the adoption of on-farm practices for control of LBI from a multi-stakeholder perspective. Our methodology comprises 4 steps, each providing groundwork for the following: 1) Knowledge Synthesis will provide insights into Canada’s current situation of LBI and evidence of change throughout time; 2) Questionnaire administered to industry stakeholders (producers, advisors, milk processors, policy-makers, consumers) will investigate perceptions, needs and actions towards LBI; 3) Focus Groups will provide insights into stakeholders’ perceived role and barriers in adopting changes to improve LBI; and 4) knowledge gathered in steps 1-3 will create a platform to develop a plan for Knowledge Translation and Transfer (KTT) to support future extension efforts. Our study will be the first to engage a wide variety of dairy industry stakeholders nationwide to explore factors impacting their perceptions towards LBI and towards change. The outcome will be used to tailor KTT tools applicable to dairy farmers throughout Canada.

Voir la description complète du projet
Superviseur du corps professoral :

Daniel Weary

Étudiant :

Partenaire :

Lactanet (QC)

Discipline :

Life Sciences

Secteur :

Agriculture

Université :

The University of British Columbia

Programme :

Elevate

Chemically upgradation and hybrid biocatalytic valorization of lignin into green aviation ligno-jet fuel and paraffinic hydrocarbons

‘Low-Carbon Fuels’ refer to fuels produced from biological and waste resources with lower lifecycle greenhouse gas emissions than fossil fuels. This project, supported by Suncor and performed at Ryerson University, aims to explore the use of innovative biocatalytic and catalytic processes to produce drop-in ligno-biojet fuel from lignin. A single biochemical step will be utilized to convert degraded lignins into hydrocarbons, and after subsequent catalytic hydrodeoxygenation using novel catalysts, into aviation fuels. The use of second-generation feedstocks (e.g. forestry biomass and pulp mill waste) is the most attractive pathway to support the large-scale deployment of sustainable and economically attractive low-carbon biojet fuels in the near future. This project is well aligned with Suncor’s GHG performance goal of reducing the emissions intensity of their products by 30% by 2030, and is aligned with Canada’s plan to achieve net-zero emissions by 2050.

Voir la description complète du projet
Superviseur du corps professoral :

Yaser Dahman

Étudiant :

Partenaire :

Suncor Energy Inc (Calgary, AB)

Discipline :

Life Sciences

Secteur :

Mining; Wholesale trade

Université :

Toronto Metropolitan University

Programme :

Accelerate

Role of cannabinoids on fast-inactivation of cardiac Nav channels – Year two

Cannabinoids are natural products derived from the Cannabis sativa plant (commonly known as marijuana). Cannabidiol (CBD), the main non-psychotropic cannabinoid is reputed to have medicinal benefits and is approved for the treatment of two seizure disorders. Other non-psychotropic cannabinoids, like cannabinol and cannabigerol, are less studied. We previously found that CBD both directly and indirectly affects voltage-gated sodium channel (Nav) function. The direct effects of CBD on Nav involve sodium current reduction, which we suggest is caused by a physical block of the channel; the mechanism of this block remains unknown. We now seek to gain more detailed knowledge of how CBD and other cannabinoids directly affect the biophysical properties of the cardiac Nav channel (Nav1.5) by measuring Nav1.5 gating charge movements. Notably, CBD reduces seizure activity associated with Dravet Syndrome, an inherited seizure disorder caused by mutations in neuronal Nav channels. Therefore, we aim to further determine if cannabinoids could be used to reduce proarrhythmic activity associated with long-QT 3 (LQT3), an inherited heart disease caused by mutations in Nav1.5.

Voir la description complète du projet
Superviseur du corps professoral :

Peter Ruben

Étudiant :

Partenaire :

Akseera Pharma Corp

Discipline :

Life Sciences

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

Simon Fraser University

Programme :

Elevate

Realistic and High-Performance Rendering

State-of-the-art computer graphics technology allows for the generation of images and animations that border on photo-realistic quality; however, this level of fidelity is often reserved for feature-film productions where the time budget is much more flexible. In the case of interactive graphics, such as approaches that are used in video games, similar demands are made on the quality of the computer graphics output, however much more restrictive computation budgets are imposed: for example, each frame of a computer graphics animation in a video game must be computed in a fraction of a second, as opposed to several hours (the typical budget allotted in feature-film animations). As such, developing interactive image synthesis (rendering) algorithms capable of delivering both high-fidelity results, as well as doing so using very little computation time, is a challenging problem in both applied and theoretical computer graphics. This MITACS Cluster will segment and address several important problems…

Voir la description complète du projet
Superviseur du corps professoral :

Derek Nowrouzezahrai

Étudiant :

Partenaire :

Microsoft Canada

Discipline :

Computer science

Secteur :

Information and Communications Technology

Université :

Université de Montréal

Programme :

Accelerate

Role of cannabinoids on fast-inactivation of cardiac Nav channels

Cannabinoids are natural products derived from the Cannabis sativa plant (commonly known as marijuana). Cannabidiol (CBD), the main non-psychotropic cannabinoid is reputed to have medicinal benefits and is approved for the treatment of two seizure disorders. Other non-psychotropic cannabinoids, like cannabinol and cannabigerol, are less studied. We previously found that CBD both directly and indirectly affects voltage-gated sodium channel (Nav) function. The direct effects of CBD on Nav involve sodium current reduction, which we suggest is caused by a physical block of the channel; the mechanism of this block remains unknown. We now seek to gain more detailed knowledge of how CBD and other cannabinoids directly affect the biophysical properties of the cardiac Nav channel (Nav1.5) by measuring Nav1.5 gating charge movements. Notably, CBD reduces seizure activity associated with Dravet Syndrome, an inherited seizure disorder caused by mutations in neuronal Nav channels. Therefore, we aim to further determine if cannabinoids could be used to reduce proarrhythmic activity associated with long-QT 3 (LQT3), an inherited heart disease caused by mutations in Nav1.5.

Voir la description complète du projet
Superviseur du corps professoral :

Peter Ruben

Étudiant :

Partenaire :

Akseera Pharma Corp

Discipline :

Life Sciences

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

Simon Fraser University

Programme :

Elevate

Transforming Financial Planning Software

Canadians spend a lot of time worrying about personal finances, investing and planning for the future. Sound strategies for managing and building wealth have a real impact on financial outcomes, however, navigating financial, estate and tax planning is difficult and many key pieces are easily overlooked. Current solutions focus too narrowly on retirement or rely too heavily on costly professionals. To address these issues, this research project is an opportunity to bring together Planworth’s financial, tax and estate planning know-how with the Schulich MBAN program’s mathematical and analytical expertise to build a more accessible, transparent and understandable solution that will help individuals find the best way to earn, save, invest and spend their money based on their goals, applicable tax rules and broader economic conditions, now and over time. The research partnership between Planworth and the Schulich MBAN program has the potential to transform an industry.

Voir la description complète du projet
Superviseur du corps professoral :

Murat Kristal;Hjalmar Turesson

Étudiant :

Partenaire :

Planworth Inc.

Discipline :

Business

Secteur :

Information and cultural industries

Université :

York University

Programme :

Accelerate

Quantifying community-level responses to anthropogenic landscape disturbance and management using multi-array camera trap data

Habitat loss through anthropogenic landscape disturbance is one of the leading drivers of biodiversity loss, yet activities such as resource extraction and agriculture play a vital role in the global economy. Understanding impacts of such disturbances, through robust environmental monitoring protocols, is key to maintain a balance between economic growth and environmental sustainability. Cost-effective monitoring approaches that collect data at a broad yet relevant scale for investigating species responses to disturbance is required. We propose the use of a network of multiple camera trap arrays within a coordinated distributed experiment framework to monitor and assess mammalian responses to resource extraction activities and wildlife management interventions aimed at mitigating negative impacts of such activities. We will deploy– leverage data previously collected from– a large network of standardized camera trap arrays distributed across a gradient of disturbance within Alberta and exposed to different management practices. to design, evaluate and apply a robust protocol that can be used to monitor multi-species responses to disturbance long- term. Such a program will be invaluable to land managers, both within Western Canada and beyond, by increasing our understanding of broad-scale responses to landscape disturbance and allowing better-informed wildlife management interventions.

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Superviseur du corps professoral :

Jason T Fisher

Étudiant :

Partenaire :

InnoTech Alberta

Discipline :

Life Sciences

Secteur :

Sustainability & the Environment; Life Sciences (not health); Environmental Science and Technology

Université :

University of Victoria

Programme :

Elevate

Beyond Covid-19: infusing interactive multi-sensory physical movements to a new model of children’s adaptation for the new normal – Year two

The Mental Health Commission of Canada indicates that approximately 1.2 million children and youth in Canada are suffering with mental illness; however, only 20% receive proper treatment. Studies have shown that the pandemic impacts children’s physical and mental health, and children are now experiencing increased mental health and physical challenges as a result of COVID-19. Do we — as parents and early childhood educators — have plans to protect, recast, and reinvigorate children’s physical and mental health in the new normal? Do we have any plans that might transform stressful problems and trauma into a source of emotional energy that can be met with meaningful and interesting innovation? This research is focused on expanding mental-health strategies using interactive multi-sensory physical movements (IMPM) to prevent mental illness in both mainstream and special education settings. Expected results are to design an IMPM model which accounts for the children’s mental and physical needs in order to integrate designed activities into scientific instruments (applications of holography) employing look/see, hear, touch, smell, taste, feel, think, speak, and full body motions. This model is feasible and accessible within a new innovative kindergarten curriculum/program.

Voir la description complète du projet
Superviseur du corps professoral :

Mary Bernard

Étudiant :

Partenaire :

Mencius Consulting Limited

Discipline :

Sociology

Secteur :

Professional, scientific and technical services

Université :

Royal Roads University

Programme :

Elevate

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