Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30 508 projets complétés

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825
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681
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860
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586
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Projets par catégorie

How interindividual differences in brain anatomy shape mathematical abilities

A specific region of the brain, the intra-parietal sulcus (IPS) has reliably been shown, through studies using a variety of methodologies (brain injury, developmental abnormality and neuro-imaging studies), to be a crucial substrate for mathematical competence (Brannon, 2006; Bugden, Price, McLean, & Ansari, 2012; Dehaene, 2004; Dehaene, Piazza, Pinel, & Cohen, 2003; Holloway & Ansari, 2010; Kaufmann, Wood, Rubinsten, & Henik, 2011; Piazza, Pinel, Le Bihan, & Dehaene, 2007). Whilst most research has focused on the brain regions supporting numerical processing, few studies have examined the influence of intra-individual differences in neuro-anatomy on mathematical competence.
Using anatomical MRI we shall investigate whether the sulcal pattern of the IPS, a brain feature determined in utero and stable after birth (Cachia et al., 2016; Chi, Dooling, & Gilles, 1977; Mangin, Jouvent, & Cachia, 2010; Sun et al., 2012), was associated with mathematical competence. TO BE CON’T

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Superviseur du corps professoral :

Daniel Ansari

Étudiant :

Partenaire :

Université Paris Cité

Discipline :

Life Sciences

Secteur :

Education

Université :

Western University

Programme :

Globalink Research Award

A Process Integration Approach of CO2 Sequestration to Marketable Products

The catalytic CO2 reforming process provides a sequestration alternative that holds promise for a viable solution for dealing with industrial gaseous effluents containing greenhouse gases CH4 and CO2. The process converts these gases to syngas (CO and H2) which can be used for synthesis for high value chemicals. The catalyst for the dry reforming process has been developed by Enerkem and is being scaled up by an industrial partner for implementation in an industrial sized reactor. Further, the syngas produced from this process can be used for an environment friendly alternative route for carbonylation step utilizing bio-based methanol/DME that could lead to higher value products ranging from acetic acid to acrylic acid. The final project deliverable would be an integrated process flow diagram (PFD) with stream tables with materials and energy balance with performance as indicated and reduces the green house emissions as projected.

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Superviseur du corps professoral :

Natalia Semagina

Étudiant :

Partenaire :

Enerkem (Edmonton, AB)

Discipline :

Engineering

Secteur :

Manufacturing

Université :

University of Alberta

Programme :

Accelerate

Multidimensional screening with general nonlinear preferences

As a central problem in modern microeconomic theory, multidimensional screening plays a significant role in taxation theory, regulation, nonlinear pricing, insurance, etc. Starting from eminent work of Nobel Laureates Mirrlees, Spence and Myerson, there are two main types of generalizations: one is in terms of dimensionality, from one-dimensional to multi-dimensional; the other is in preferences form, from quasilinear to general nonlinear.
For the multidimensional quasilinear case, theories of existence, uniqueness, and robustness have been widely studied. However, for the multidimensional general nonlinear case, existence (2015, 2017) and uniqueness (2017) results are unknown until recently. Thus, it is natural to solve the unique solution of this optimization problem and explore its economic interpretations, which is one of our objectives.
There might be very fruitful to study other potential economic applications in game theory, including actions, pre-event ticket sales, and competition in dynamic mechanisms. TO BE CONT’D

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Superviseur du corps professoral :

Robert J. McCann

Étudiant :

Partenaire :

Université Paris Dauphine

Discipline :

Mathematics

Secteur :

Université :

University of Toronto

Programme :

Globalink Research Award

Interaction and assembly of the spliceosomal Sm complex in Cyanidioschyzon merolae

Some biochemical processes are challenging to be studied due to the number of components that they are comprised. Splicing is a challenging process that involves removal of unnecessary information from messenger RNA for synthesis of a protein of interest. This process gives raise to much of the protein diversity in humans; therefore, it is not surprising that a great number of diseases can be linked to defects in splicing. We have identified an unique reduced splicing machinery in a red alga, Cyanidioschyzon merolae, being a great model of study. Here, it is investigated one of the splicing complexes characterized in this alga, Sm complex, comprised of seven proteins. I have been able to successfully synthesize this complex allowing investigation of its binding to other splicing components. However, its assembly is unrevealed since the proteins involved in this process are absent in this alga.TO BE CONT’D

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Superviseur du corps professoral :

Stephen Rader

Étudiant :

Partenaire :

Université de Montpellier

Discipline :

Life Sciences

Secteur :

Education

Université :

University of Northern British Columbia

Programme :

Globalink Research Award

O-GlcNAc, a novel strategy to treat acute cardiovascular shock and improve survival

Septic shock is an acute pathology that is the leading cause of admission to ICUs across Canada, and the developed world. Unfortunately, no treatment to date has yet to be proven beneficial. Cardiac failure is a major factor in the mortality induced by septic shock. A major player to be targeted in treating this dysfunction are the mitochondria. The Ottawa-Nantes Sepsis Therapy (ONSET) collaboration will bring two groups of cardiovascular experts to address this pressing issue. Together, this research project will look to formulate novel pre-clinical evidence for the cardiac mito-protective effect of O-GlucNAcylating compounds, a post-translational modification proven to be beneficial in early phase sepsis by the Lauzier Lab in Nantes. The expertise of the Burelle Lab (Canada) in mitochondrial bioenergetics, and working with pharma companies who produce said compounds, will lead to a better understanding of the mechanism of septic injury and potential mito-targeted drug therapies.

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Superviseur du corps professoral :

Yan Burelle

Étudiant :

Partenaire :

Nantes Université

Discipline :

Life Sciences

Secteur :

Education

Université :

University of Ottawa

Programme :

Globalink Research Award

Caractérisation des communautés de joueurs pour le jeu vidéo Dead by Daylight

À la sortie d’un jeu vidéo en ligne, une communauté s’organise autour du jeu, créant une culture, des pratiques de jeu, des attentes et des formes d’appropriation qui peuvent diverger des intentions initiales du développeur du jeu, mais qui, pourtant, ont des effets majeurs sur le succès ou non d’un jeu. L’objectif principal de ce projet est alors de caractériser la communauté du jeu vidéo Dead by Daylight (2016) de Behaviour Digital à travers l’analyse des activités des joueurs sur les forums et les réseaux socionumériques ainsi que l’analyse des données de tracking ingame. L’expertise de l’UQAM associée à celle des employés chez Behaviour permettra une connaissance plus approfondie de la communauté de Dead by Daylight, ce qui aidera à la gestion de la communauté, fournira des éléments clefs pour l’amélioration et l’opération en temps réel du jeu et favorisera ainsi le succès à plus long terme de ce jeu.

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Superviseur du corps professoral :

Maude Bonenfant

Étudiant :

Partenaire :

Behaviour Interactive

Discipline :

Sociology

Secteur :

Arts, entertainment and recreation; Information and cultural industries; Professional, scientific and technical services

Université :

Université du Québec à Montréal

Programme :

Accelerate

Investigating vestibular changes in patients with post-concussion syndrome (PCS) in relation to the comorbid depression

This proposal presents two parallel research projects to develop pattern recognition algorithms using a relatively new technology, Electrovestibulography (EVestGTM)1 for objectively and accurately effect of confounding depression on concussion both when used as a diagnostic tool and also as a treatment recovery tool. EVestG signals are recorded painlessly and non-invasively from the external ear in response to a vestibular stimulus; they are the brain signals modulated by the vestibular response. When concussed, people commonly experience balance (vestibular) problems and dizziness, as well as confused thinking. In our previously funded MITACS projects2 we have shown that EVestG has potentials to be a reliable diagnostic tool for post-concussion syndrome (PCS) and also monitoring its recovery. TO BE CONT’D

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Superviseur du corps professoral :

Zahra MK Moussavi;Brian Lithgow

Étudiant :

Partenaire :

Riverview Health Centre Foundation

Discipline :

Engineering

Secteur :

Health and Related Sciences & Technology

Université :

University of Manitoba

Programme :

Accelerate

Role of astrocyte CB1 receptor in the regulation of energy balance

Proper functioning of astrocytes and of the endocannabinoid system in the hypothalamus has been strongly linked to feeding behaviour and energy balance in mice. Furthermore, a strong molecular link has been found to connect cannabinoid receptors to leptin (a hunger hormone) receptors in hypothalamic astrocytes. Specifically, deletion of cannabinoid receptors in hypothalamic astrocytes disrupted the formation of leptin receptors and their signalling pathway. The objective of this project is to test the importance of astrocyte cannabinoid receptors in feeding behaviour. The mouse model used for the project permits the inducible deletion of cannabinoid receptors (CB1) in astrocytes, specifically. These CB1 knockout mice will be treated in vivo with a variety of metabolic challenges including fasting and refeeding, acute leptin injection and exposure to high fat diet. TO BE CONT’D

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Superviseur du corps professoral :

Jaideep Bains

Étudiant :

Partenaire :

Université de Bordeaux

Discipline :

Life Sciences

Secteur :

Université :

University of Calgary

Programme :

Globalink Research Award

Supramolecular Hydrogels as new stimulable drug delivery systems

This project is based on the development of a new spatiotemporal release system for combination of active principle ingredients (API) under mechanical stimuli. The therapeutic schemes for some pathologies is based on the use of combined drugs to improve the efficiency or reduce the risk of resistance (cancer, infection treatments). Moreover, the use of hydrogels as drug delivery systems enables to reduce side effects due to a localized effect. Combining all these elements, the student will work on the formulation of stimulable supramolecular hydrogels. The molecules synthetized in our laboratory have the properties under high stress to go from a gel state to a liquid state. The formulation go back to its initial state (gel) when the stress is removed (just like ketchup). It’s very useful for hydrogel injection. In these news biomaterials, several API will be added to obtain combined therapies. TO BE CONT’D

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Superviseur du corps professoral :

Chris Flinn

Étudiant :

Partenaire :

Université de Bordeaux

Discipline :

Life Sciences

Secteur :

Université :

Memorial University of Newfoundland

Programme :

Globalink Research Award

Uncertainties in space debris dynamics due to space weather

The increase in Earth-orbiting space debris has been the cause of significant debate over the last decade. More than 29,000 objects larger than 10 cm have been detected in orbit and it is estimated that more than 170 million particles above 1mm populate the near-Earth environment. Potential collisions between active satellites and space debris are thus becoming an increasing threat to space operations. Research into mitigation strategies and debris removal efforts have been plentiful, but accurate knowledge of debris dynamics and prediction of their orbital and attitude motion is crucial for the safety and success of future missions. Many environmental factors affect an orbiting body’s orbit and spin rate, such as aerodynamic drag, solar radiation, and interactions with Earth’s magnetic field. All of these perturbations are highly dependent on disturbances occurring around Earth due to space weather. TO BE CONT’D

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Superviseur du corps professoral :

Inna Sharf

Étudiant :

Partenaire :

Paris Observatory

Discipline :

Engineering

Secteur :

Université :

McGill University

Programme :

Globalink Research Award

Nano and Macroscale Tribological Investigation of MoS2 and MoST

Since the beginning of space exploration is has become apparent that lubrication between surfaces in space would face many challenges that aren’t relevant on earth. Friction and wear testing on earth has been developed in turn to emulate the conditions that would be faced by solid lubricants in outer space. This requires specific contact geometries and forces, as well as control of environmental conditions including chemistry, pressure, humidity, and temperature. While studies performed in Toronto will allow for nanoscale tribology tests, access to the highly atmosphere-controlled mechanism-scale Tribowave tribometer in Lyon would allow for the currently uninvestigated comparison between the nanoscale evolution of a lubricant and the macroscale effects of an application driven contact. Furthermore, video and chemical analysis of the sample during the tribological contact during testing is a capability unique to the Tribowave tribometer in Lyon. TO BE CONT’D

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Superviseur du corps professoral :

Tobin Filleter

Étudiant :

Partenaire :

Institut National des Sciences Appliquées de Lyon

Discipline :

Engineering

Secteur :

Université :

University of Toronto

Programme :

Globalink Research Award

DNA as the addressable element in mesoporous silica particles

Oligonucleotides will be structurally integrated within complementary architectures in order to synthesize hybrid nanomaterials featuring biomolecular-driven behavior. We plan to synthesize nanoparticles featuring nucleic acid conjugates embedded in the structural network, so that their dynamics could be programmed for cancer therapy. We intend to make use of the biodegradable organosilica technology developed in De Cola’s laboratory at the University of Strasbourg (UNISTRA), not otherwise available at McGill University. The principal aim would be to exploit physical, chemical and biological properties of nanosystems that will be utilized as drug delivery carriers and functional therapeutics for advanced personalized nanomedicine applications. The outcomes of this experience will provide fundamental knowledge towards developing novel functional nanomaterials that can help to go beyond the state-of-the-art of drug delivery systems currently used for biomedical treatments.

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Superviseur du corps professoral :

Hanadi Sleiman

Étudiant :

Partenaire :

Université de Strasbourg

Discipline :

Physics

Secteur :

Education

Université :

McGill University

Programme :

Globalink Research Award

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