Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

31 132 projets complétés

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5159
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837
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685
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882
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9291
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9695
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97
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601
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1161
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Projets par catégorie

Improving the efficacy of lung delivery of gene editors through optimized lipid nanoparticle formulations to repair cystic fibrosis-associated mutations in human lungs

Cystic fibrosis (CF) is one the most common life-shortening inherited diseases. In the past, patients rarely survived into adulthood; and currently, even with treatment, patients still often require difficult lung transplants. New drugs called protein modulators are a game-changer for CF patients; however, they require twice daily lifelong administration and cannot offset the pre-existing lung damage. Importantly, these drugs are also not effective for all patients, leaving a significant gap in the treatment options. Researchers have recently begun to demonstrate the utility of new gene editing technologies to correct CF-causing mutations. However, critical gaps remain in demonstrating therapeutic levels of correction in patient lung cells, in using clinically relevant delivery strategies, and in establishing the safety and specificity of gene editing technologies. This project aims to use patient lung cells, the gold-standard predictive model in CF drug development, to evaluate and compare new gene editing and delivery technologies. Broadly, this research will aid the development of future gene editing strategies for lung diseases, and specifically will provide the pre-clinical validation for new gene editing treatments for CF.

Voir la description complète du projet
Superviseur du corps professoral :

Colin Ross;Sarah Hedtrich

Étudiant :

Partenaire :

Acuitas Therapeutics

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

The University of British Columbia

Programme :

Elevate

Dynamic polymer additives for recycling polyvinylchloride

Polyvinylchloride’s (PVC’s) exceptional mechanical properties and chemical stability make it an ideal material for applications in infrastructure. The PVC pipes that are widely used in municipal water systems, irrigation, and industry are sustainable, long-lasting, and resistant to weathering and leaking. Yet, degradation during recycling makes PVC exceedingly difficult to recycle, limiting its sustainability. Phthalate plasticizers and organotin stabilizers mitigate the degradation challenges associated with recycling. Yet, these plasticizers and stabilizers are toxic and can compromise the mechanical properties that make PVC so advantageous. We propose a novel approach to improving the recyclability of PVC that would not compromise the mechanical properties of the recycled materials. Dynamic polymers will be developed as temperature-responsive plasticizers for PVC recycling. These polymers will be designed to deconstruct into plasticizers in response to the high temperatures associated with PVC recycling, making the melt reprocessable. Upon cooling post-recycling, the plasticizers will reconnect into high molecular polymers, thereby preventing them from leaching, while also minimizing their impact on the mechanical properties of the recycled PVC materials. The dynamic polymers will be prepared by adding thermally dynamic Diels-Alder adducts into the backbone of polyacrylates by radical ring-opening polymerization.

Voir la description complète du projet
Superviseur du corps professoral :

Elisabeth Prince

Étudiant :

Partenaire :

IPEX Technologies Inc

Discipline :

Engineering

Secteur :

Manufacturing

Université :

University of Waterloo

Programme :

Accelerate

A Wearable Electrical Vestibular Stimulation System for Tracking and Enhancing Human Balance and Gait

The vestibular balance system detects linear and angular head motion and plays a role in stabilization of human balance and walking. Age-related vestibular disruptions increase fall risks for a large fraction of our elderly populations and make it increasingly difficult to continue living activity and independently, both of which have very large associated healthcare costs. As a result, there is a large unmet need for lower cost and more widely accessible diagnostic and therapeutic solutions that target impairments to the human vestibular balance system. Current wearable devices can only monitor human movement, so a wearable device that can both diagnose and treat human balance and gait impairments represents a fundamental new capability. Neursantys has developed such a device by integrating the company’s innovations in non-invasive balance and gait impairment diagnostic sensor technology, non-invasive electrical vestibular stimulation (EVS)-based balance therapeutics, and machine-learning based device automation. The ease of use and wearable form factor of the Neursantys solution further enable its use for both in-clinic and remote patient care, providing a convenient, low-cost alternative to improve patient quality of care and reduce health care costs. In this project we will
• assess the feasibility of Neursantys diagnostic sensor technology to measure balance and gait stability while walking;
• rigorously test and quantify the ability of the Neursantys electrical vestibular stimulator to enhance balance while walking, similar to the human vestibular system;
• assess corresponding improvements in elderly population and healthcare utilization

Voir la description complète du projet
Superviseur du corps professoral :

Ryan Peters;Arthur Kuo

Étudiant :

Partenaire :

Neursantys

Discipline :

Engineering

Secteur :

Professional, scientific and technical services

Université :

University of Calgary

Programme :

Elevate

Estimating Risk and Testing Based on Change for Assets, Visual Code, and Textual Code

Video games are complex data driven software systems. The data is the levels and objects inside of the levels. These objects are programmed using visual programming languages and textual programming languages. Current software engineering support for visual languages is in its infancy and the tools that software engineers rely upon are often not available in visual languages. Companies like Electronic Arts rely on these languages and assets to create immersive entertaining video games, but as games increase in size and complexity so do quality issues and errors. We seek to provide insight to game designers and software developers to help them identify where errors and quality issues are coming from, whether it be a 3D model of a mountain range, or visual code that opens a door on a map.

Voir la description complète du projet
Superviseur du corps professoral :

Abram Hindle

Étudiant :

Partenaire :

Electronic Arts Canada (Burnaby, BC)

Discipline :

Computer science

Secteur :

Information and cultural industries

Université :

University of Alberta

Programme :

Accelerate

Développement d’outils prédictifs de la qualité de la crème pour contrôler le procédé de production et les propriétés rhéologique du beurre

Le projet de recherche proposé vise à résoudre les défis rencontrés par les entreprises de transformation, comme Agropur, dans la production de beurre, où l’utilisation de crèmes de qualité variable entraîne une grande variation dans la composition et l’historique de production. Pour remédier à cela, le projet se concentre sur le développement d’outils analytiques et de méthodes d’analyse en ligne pour identifier les étapes critiques de production et prédire le comportement des crèmes de qualité variable. En utilisant la spectroscopie infrarouge pour recueillir en continu des données sur la transformation de la crème en beurre, et en appliquant des techniques d’intelligence artificielle et de chimiométrie, le projet vise à modéliser les changements physiques et chimiques affectant la texture finale du beurre. Cette approche permettra de mieux comprendre l’impact de l’historique de la crème sur la qualité du produit final et de proposer des mesures correctives en temps réel, améliorant ainsi la qualité et l’efficacité de la production de beurre pour les entreprises partenaires comme Agropur.

Voir la description complète du projet
Superviseur du corps professoral :

Guillaume Brisson;Christophe Cordella

Étudiant :

Partenaire :

Agropur Coopérative

Discipline :

Life Sciences

Secteur :

Manufacturing

Université :

Université Laval

Programme :

Elevate

PARAMETRIC IMAGING OF MYOCARDIAL BLOOD FLOW WITH RUBIDIUM-82 PET

This project aims to improve medical isotope imaging for the diagnosis of patients with heart disease, specifically those with plaque buildup in the arteries that supply blood to the heart muscle.

Voir la description complète du projet
Superviseur du corps professoral :

Robert deKemp

Étudiant :

Partenaire :

Siemens Healthcare Limited

Discipline :

Engineering

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

University of Ottawa

Programme :

Elevate

RAMP: Restorative Approach to Multiple Proceedings

The findings of the Nova Scotia Home for Colored Children Restorative Inquiry, the Mass Casualty Commission, the National Inquiry into the Missing and Murdered Indigenous Women and Children, and the Truth and Reconciliation Commission, confirm that family and gendered violence is a systemic issue that necessitates immediate innovative responses. One aspect of the structural perpetuation of gender-based violence is the complexity of the justice and legal systems in which people experience gender-based violence often find themselves. Too often people who experience gender-based violence are engaged in multiple court proceedings simultaneously. Those most directly impacted by family violence often find themselves having to simultaneously navigate the complexities of a criminal court process, family court process, and child and family wellbeing processes. During an extremely stressful period, families are also required to adhere to multiple, and sometimes contradictory, court orders and other requirements. The Restorative Approach to Multiple Proceedings (RAMP) initiative brings together system and community-based partners to trailblaze a restorative approach to cases of family violence involving multiple proceedings.

Voir la description complète du projet
Superviseur du corps professoral :

Jennifer Llewellyn

Étudiant :

Partenaire :

Elizabeth Fry Society of Mainland NS

Discipline :

Sociology

Secteur :

Health and Related Sciences & Technology

Université :

Dalhousie University

Programme :

Accelerate

Analyses du potentiel d’utilisation des autres mesures de conservation efficaces par zone (AMCE) pour la connectivité d’un réseau écologique dans le sud du Québec

La perte d’habitats mène à la fragmentation du paysage, ce qui engendre des changements dans la structure et le fonctionnement des écosystèmes résiduels tout en provoquant également des pertes de biodiversité, de fonctions et de services écologiques. Ce phénomène risque de s’accentuer dans les prochaines décennies en raison des changements globaux et de l’accroissement de la population humaine. Le maintien de la connectivité du paysage par l’établissement d’aires protégées est une solution souvent préconisée pour favoriser la résilience des populations animales et végétales à la fragmentation. Cependant, dans un contexte de terres privées, comme dans le sud du Québec, l’établissement d’aires protégées est difficile en raison des conflits d’usage et du régime de gouvernance des terres. Un nouvel outil de conservation, soit les autres mesures de conservation efficaces par zone (AMCE), présente un potentiel fort intéressant dans ce contexte, car il permettrait de faire reconnaître la contribution d’un territoire pour la conservation de la biodiversité tant que celui-ci ne présente pas d’activités incompatibles. Cependant, cet outil est toujours en développement au Québec et son potentiel demeure largement inexploré. L’objectif du projet est donc de mesurer le potentiel des AMCE pour la connectivité d’un réseau écologique dans le sud du Québec

Voir la description complète du projet
Superviseur du corps professoral :

Jerome Cimon-Morin

Étudiant :

Partenaire :

La Société canadienne pour la conservation de la nature

Discipline :

Earth science

Secteur :

Professional, scientific and technical services; Real estate and rental and leasing

Université :

Université Laval

Programme :

Accelerate

Redefining Cancer Risk Assessment Using Duplex Sequencing

The current gold standard to assess cancer risk of chemicals and other consumer products is the 2-year rodent cancer bioassay, which is time-consuming, expensive, and does a poor job at predicting the potential for cancer in humans. DupSeq is a cutting-edge, ultra-precise genetic analysis tool that can identify subtle changes in DNA, providing more comprehensive insights into potential cancer risks. Our ultimate goal is to make DupSeq the gold standard for cancer risk assessment globally. To achieve this, our project collaborates with partners from different sectors within the Health and Environmental Sciences Institute. We are collecting data to establish methods and optimize DupSeq’s performance for regulatory testing of chemicals and drugs. We will also develop computational tools to streamline DupSeq data analysis. Once methods are refined, we will use DupSeq to investigate real-world applications by examining how a complex chemical mixture found in the environment impacts mice when exposed before birth. This is pivotal because there is an urgent need to fill current knowledge gaps regarding cancer risks from prenatal exposures. By addressing these uncertainties, our project aspires to revolutionize cancer risk assessment globally, making DupSeq an indispensable tool for quickly and affordably ensuring public safety.

Voir la description complète du projet
Superviseur du corps professoral :

Carole Yauk;Francesco Marchetti

Étudiant :

Partenaire :

TwinStrand Biosciences;Charles River Laboratories;HESI

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Ottawa

Programme :

Elevate

Design and Implementation of a Filtration and Capture System for an Underwater Remotely Operated Vehicle Removing Ship Pollutants

In this project, an underwater remotely operated vehicle (ROV) from the industry partner EcoMarine Technologies Inc is used to navigate underwater to execute the tasks of capturing and filtering the biofouling when performing hull cleaning for ships in the ocean. In order to avoid harmful debris being released into the sea when cleaning, environmentally friendly and economically viable solutions would be needed. Sensors and actuators will be integrated to a filtration system and capture system for the ROV. The system is used to deal with a wide range of pollutants such as plastics, metals, and organic waste in the ocean. Two main modules will be designed. The first one is the design of a modular and efficient filtration system which is capable of filtering varying pore sizes of different pollutants. The design is scalable and adaptable to different sizes of ROVs. The second one is the capture and storage system to minimize the human exposure to hazardous materials, easy for operation, and with smart sensors for monitoring the amount of captured pollutants. The principle is that the overall process should not disturb marine life in the underwater environment. Extensive testing will be carried out to refine the design.

Voir la description complète du projet
Superviseur du corps professoral :

Ya-Jun Pan

Étudiant :

Partenaire :

EcoMarine Technologies

Discipline :

Engineering

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

Dalhousie University

Programme :

Accelerate

Structural and lithological controls and hydrothermal evolution of the 123 ore zone, Casa Berardi deposit

The Casa Berardi mine is a significant gold producer in the northern Abitibi area. Exploration efforts for new mineralized zones in this region is complicated by a thick cover of surficial deposits and new exploration tools based on a better understanding of gold concentration are necessary to guide future exploration at depth. This project proposes to use one of the main ore zones of the Casa Berardi underground mine to document the stratigraphic and structural features, and the auriferous hydrothermal events that led to the formation of the higher grade mineralized zones. This will help to understand the timing of gold introduction relative to the complex geological history, and to identify the favorable context and guidelines for exploration of the Casa Berardi deposit, but also in this part of the Abitibi greenstone belt, which is much less understood relative to the Val-d’Or, Kirkland Lake or Rouyn-Noranda areas. To do so, it is proposed to undertake a detailed mapping program and conduct a mineralogical and geochemistry study of the ores and host rocks, that will be combined with U-Pb geochronology and geothermometry.

Voir la description complète du projet
Superviseur du corps professoral :

Stéphane de Souza

Étudiant :

Partenaire :

Hecla Québec

Discipline :

Earth science

Secteur :

Mining

Université :

Université du Québec à Montréal

Programme :

Accelerate

Predicting Supercapacitor Performance Using Reinforcement Learning Methodology

In this proposal, intern will be tasked with reinforcement learning algorithm to refine the process of material selection. This method of machine learning is designed to iteratively enhance decision-making, ensuring the most effective materials are identified for various applications. The focus will be on aligning the materials’ performance characteristics with their intended use. As a result, the partner company will gain access to innovative approaches in material selection that could lead to improved product development and a stronger market position.

Voir la description complète du projet
Superviseur du corps professoral :

Hadis Zarrin

Étudiant :

Partenaire :

Sensofine Inc

Discipline :

Engineering

Secteur :

Manufacturing

Université :

Toronto Metropolitan University

Programme :

Accelerate

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Mitacs est financé par le gouvernement du Canada, le gouvernement de l’Alberta, le gouvernement de la Colombie-Britannique, Research Manitoba, le gouvernement du Nouveau-Brunswick, le gouvernement de la Nouvelle-Écosse, le gouvernement de l’Ontario, Innovation PEI, le gouvernement du Québec, le gouvernement de la Saskatchewan, le gouvernement de Terre-Neuve-et-Labrador et le gouvernement du Yukon.