Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

29 670 projets achevés

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Projets par catégorie

Deciphering the immunosuppressive functions of viral glycoproteins

Embedded in the surface of a virus, are different types of proteins that the virus uses to enter a host cell. These so-called viral glycoproteins are pivotal targets of the host antibody response to fight a viral infection. In recent decades, it has become clear that certain viral glycoproteins have evolved clever ways to suppress the immune activators on the host cell. Certain regions on viral glycoproteins directly contribute to immune evasion by misdirecting antibody responses, affecting intracellular signaling and hampering cytokine production. However, the molecular mechanisms that underlie these immunomodulatory functions of viral glycoproteins at initial stages of infection remain elusive. During his 9-month project, Bart will seek to elucidate how immunosuppressive motifs on viral fusogens from Ebola, HIV-1 and other retroviruses, are able to modulate immune activators present on the cell surface. Bart will focus on identifying the targeted immune cell populations and cell surface receptors that participate in immune suppression via binding to ISRs using flow cytometry, immunological assays to measure cytokine expression profiles and pulldown-MS work to decipher protein-protein interactions.

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Superviseur du corps professoral :

Jeffrey E. Lee

Étudiant :

Partenaire :

Leiden University

Discipline :

Life Sciences

Secteur :

Education

Université :

University of Toronto

Programme :

Globalink Research Award

Dégradation aérobie du mazout diesel n°2, bunker diesel n°6 et de l’huile à moteur

En 2010, au Québec, 73 % des terrains recensés par le Système de gestion des terrains contaminés (Système GTC), affichent une contamination de nature organique (Hébert et Bernard, 2013) Actuellement, les techniques de dégradation chimique et/ou biologique sont largement utilisés dans l’industrie, mais les résultats sont souvent décevants pour les hydrocarbures les plus lourds (Bunker diesel n°6) (Nyman, Klerks et Bhattacharyya, 2007) (Coulon et al., 2010) (Coulon et al., 2012). Le projet ci-présent vise : (1) l’optimisation des méthodes chimiques et biochimiques in situ traditionnelles de dégradation aérobie des combinaisons d’hydrocarbures, lourds et légers – bunker diesel n°6 , mazout diesel n°2, huile à moteur-; ceci par la détermination des séquences et des ratios bactéries/champignons/oxydant chimique les plus adaptés selon le contexte géochimique des terrains à l’étude; (2) la caractérisation des «voies» de dégradation des contaminants d’origine ainsi que l’atténuation de la toxicité des métabolites associés.
La finalité pour l’entreprise étant la commercialisation des «formules» de rémédiation développées

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Superviseur du corps professoral :

Alfred Jaouich

Étudiant :

Partenaire :

Enutech

Discipline :

Earth science

Secteur :

Professional, scientific and technical services

Université :

Université du Québec à Montréal

Programme :

Accelerate

Hydrogen Storage and Transportation

Without doubt, hydrogen will be a significant component of future worldwide energy supply. The main issue that hampers the use of hydrogen is related to its storage and transportation which currently uses costly high pressure or very low temperature to transport and store hydrogen. Therefore, there is an urgent need to provide a safe, efficient, and economically viable hydrogen transport and storage technology. Liquid organic compounds can store hydrogen in their structure and release it wherever there is a need for hydrogen. The technology requires efficient catalysts for storing and releasing of the hydrogen to and from the liquid organic. This project will use new, efficient catalysts as a basis to assess the techno-economic viability of the proposed hydrogen storage and transportation technology.

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Superviseur du corps professoral :

Kevin Smith

Étudiant :

Partenaire :

Springboard Atlantic Inc.

Discipline :

Engineering

Secteur :

Green/Alternative Energy; Clean Technology; Energy and Utilities

Université :

The University of British Columbia

Programme :

Accelerate

The LARP1 homolog Slr1p controls the stability and expression of proto-5’TOP mRNAs in fission yeast

Messenger RNAs (mRNAs) need to be decoded and translated into proteins in our bodies. This process must be tightly regulated by RNA-binding proteins such as LARP1. This protein is found in several organisms and by regulating mRNA translation it also regulates cell growth, but its function is poorly understood. LARP1 has been found in higher-than-normal amounts in cancerous cells therefore it is thought to lead to tumor progression and poor patient outcomes. Studying LARP1 in human cells has been challenging because of the complexity of the human system. Simpler organisms such as fission yeast also have a LARP1 protein called Slr1p, whose study has been informative towards understanding human LARP1 function. One aspect of the research in this field that has not been explored yet is how LARP1 binds mRNAs during mRNA translation. Using the simpler yeast Slr1p, we will employ Selective Translation Complex Profiling and Sequencing to identify mRNA sites where Slr1p interacts with the translation initiation machinery on its target mRNAs. This will help delineate the various confounding mRNA binding modes of LARP1 family of proteins and their functions under different circumstances and disease states.

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Superviseur du corps professoral :

Mark Bayfield

Étudiant :

Partenaire :

University of Cambridge

Discipline :

Life Sciences

Secteur :

Education

Université :

York University

Programme :

Globalink Research Award

Characterizing and modelling products recovered from gold-bearing mine tailings using a novel clean technology

AJ Min Inc. is developing a novel technology to recover gold from tailings material. The technology requires little energy, little to no reagents, and little to no additional water. Past testwork has indicated that this technology can recover significant amounts of gold from some tailings material, and that the recovered gold can be upgraded. This project will build on previous testwork to characterize the test products and develop metallurgical models to predict and improve performance. In addition, a fully automated pilot unit will be assembled, programmed, and tested.

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Superviseur du corps professoral :

Bern Klein

Étudiant :

Partenaire :

AJ Min Inc

Discipline :

Engineering

Secteur :

Mining

Université :

The University of British Columbia

Programme :

Accelerate

Formulation et évaluation de liants polymères écoresponsables pour la fabrication additive de céramiques

De nos jours, les pièces en céramique de grande précision sont généralement obtenues par moulage par injection, un procédé rentable pour la production à grande échelle, mais non viable pour la production de petites séries de pièces telles que les pièces d’horlogerie. Il est donc nécessaire de trouver de nouvelles techniques pour ce type de production. Ce projet a pour objectif d’intensifier la recherche sur les nouveaux liants biopolymères et les procédés d’impression, reconnus comme étant l’avenir en matière de fabrication, pour aboutir à des pièces fonctionnelles intégrables directement dans les systèmes d’horlogerie. Ce projet pluridisciplinaire faisant appel à trois institutions académiques (spécialisées respectivement en polymères, céramiques et contrôle non destructif) et deux partenaires privés des secteurs de l’horlogerie et de la fabrication additive. Un tel consortium permettra des avancées significatives en formulation de liants et dans la maîtrise des procédés de fabrication additive pour les céramiques.

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Superviseur du corps professoral :

Pascal Vuillaume;Saïd Elkoun

Étudiant :

Partenaire :

FABLAB Inc.

Discipline :

Engineering

Secteur :

Manufacturing

Université :

Cégep de Thetford

Programme :

Accelerate

Developing and implementing novel microfluidic scanning probes for spatial profiling of heterogenous tumor samples via a multi-omics approach

The aim of the project is to develop microfluidic technologies to analyse heterogenous tumor tissues/cells via a multi-modal approach using spatial genomic, transcriptomic and proteomic data. The resulting data obtained could be used for prognostics, diagnostics and prediction of therapies. Microfluidic scanning probes (MFP) technology, invented by the Kaigala team while at IBM Research in Zurich, that implement assays in a localised and rapid manner, is able to efficiently subtype tumor sections and is a lucrative alternative to traditional methods. We will build on TRACERx Renal study and try to improve spatio-temporal resolution in renal cell carcinoma sections by spatially profiling clonal populations within the sample using clinically annotated mutation and expression profiles. Gene-transcript data will be preprocessed using independent component analysis (ICA) strategies and its interactions will then be integrated through multiomic bioinformatic strategies. The overall objective is to specifically locate clones along with their evolutionary pathway and determine their correlation with morphological features, thus helping to bridge the gap between tumor profile and therapy.

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Superviseur du corps professoral :

Govind Kaigala

Étudiant :

Partenaire :

Goethe University Frankfurt

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology; Nanotechnology; Life Sciences (not health)

Université :

The University of British Columbia

Programme :

Globalink Research Award

Discovery of microbial enzymes for biodegradation of plastic polymers

In an effort to reach zero waste in Canada by 2030, this work is dedicated to the discovery of microbes with enzymatic capabilities to biodegrade plastic. A library of microbes (bacteria and fungi) isolated from a range of marine environments will be screened for unique and novel plastic biodegrading activities. Preferred microbes will be selected for continued study and to develop novel enzymatic methods for depolymerization of plastic. The objective is to create a fully circular plastic economy where plastic waste can be recycled without a loss in quality and valorized into new products. The academic partner (UPEI), potential start-up (MultiGenZyme), and local economy (PEI) could all benefit from this technological advancement, but the true value lies in the positive environmental impact of reducing plastic pollution.

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Superviseur du corps professoral :

Russell G. Kerr

Étudiant :

Partenaire :

Springboard Atlantic Inc.

Discipline :

Life Sciences

Secteur :

Clean Technology; Life Sciences (not health); Sustainability & the Environment

Université :

University of Prince Edward Island

Programme :

Accelerate

Formalisation d’arguments de sécurité

Le présent projet appartient au domaine de la représentation des connaissances et constitue un premier pas vers le développement d’outils informatiques en support au développement de dossiers de sécurité et d’audits de conformité reliés à la sécurité des TI. Il porte plus particulièrement sur la représentation formelle d’interprétations de requis de conformité reliés à la sécurité des TI dans des contextes vulnérables aux cyberattaques. Un tel environnement technologique permettrait, entre autres, de présenter les résultats d’analyses et d’audits de façon plus claire et uniforme, de formaliser des méthodologies liées aux audits et de faciliter la communication entre les différents acteurs du monde de la sécurité.

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Superviseur du corps professoral :

Jules Desharnais

Étudiant :

Partenaire :

Groupe de développement ICRTECH inc

Discipline :

Computer science

Secteur :

Professional, scientific and technical services

Université :

Université Laval

Programme :

Accelerate

Research on the Impacts of Automated Speed Enforcement (ASE) in Rwanda to Develop a Guide for African Countries (GRSF CFP FY21)

The proposed consultancy services are going to conduct research related to the introduction of Automated Speed Enforcement (ASE) tools in a low-income African country (based on the Rwandan case study). Quantifying the effect of installing enforcement cameras on the number of damages, injuries, fatality collisions, and traffic offenses like speeding, crossing red lights, and talking with phones can be captured in this study. In other words, the safety of areas with installed camera can be evaluated by comparing them to control sites with no installed camera. Furthermore, this project aims to consider the evaluation of characteristics surrounding collisions like causes of accidents, time and date of collisions, etc. Also, changes in the trend and seasonality of collisions due to installing enforcement cameras can be known over time in different districts of Rwanda. This research intervention will result in broadly transferable guidelines for deployment in other low- and middle-income countries.

Voir la description complète du projet
Superviseur du corps professoral :

Martin Lavallière

Étudiant :

Partenaire :

Traffic Injury Research Foundation

Discipline :

Engineering

Secteur :

Professional, scientific and technical services

Université :

Université du Québec à Chicoutimi

Programme :

Accelerate

Biodegradable, Sustainable Novel Lab Products

The special characteristics of plastics have led to them taking an essential role in society. Unfortunately, plastic consumption, production and disposal significantly impact the community. The failure of research labs to better understand the actual costs of lab plastic wastes has led to poor management of plastic materials and growing social, ecological and economic costs for countries. BioLabMate will design the novel formulation from seaweed to make the research lab plastic more eco-friendly and biodegradable. The sustainable use of seaweed-derived biopolymers is crucial to replace plasticizers with biodegradable materials and thus preserve the environment. BioLabMate” is highly focused on creating biodegradable lab products for research laboratories.

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Superviseur du corps professoral :

Lesley Anne James

Étudiant :

Partenaire :

Springboard Atlantic Inc.

Discipline :

Engineering

Secteur :

Environmental Science and Technology; Clean Technology; Sustainability & the Environment

Université :

Memorial University of Newfoundland

Programme :

Accelerate

National Marketing Project Manager

PSR Canada is a grassroots volunteer professional organization that provides education to practitioners in the field of mental health and addiction. Using its Competencies of Practice for Canadian Recovery-Oriented Psychosocial Rehabilitation Practitioners, a document compiled through the Scientific Committee of the organization, it offers a national certification program for people who want to demonstrate their skills in practising recovery-oriented services. While PSR Canada has developed a quality certification program detailing mental health recovery strategies and educational practices, it has so far struggled to market itself to achieve its mission to create wide-felt societal good. By leveraging the intern’s business and marketing expertise, PSR Canada would be able to maximize its opportunities with national partners such as the Mental Health Commission of Canada and other national organizations dedicated to mental health and addiction issues. The organization would also be able to better communicate its value proposition to its target market, increasing its certification and resources’ reach to help more people along their wellness journey.

Voir la description complète du projet
Superviseur du corps professoral :

Sandy Staples

Étudiant :

Partenaire :

Psychosocial Rehabilitation (PSR) Canada

Discipline :

Business

Secteur :

Education; Information and Communications Technology; Social Innovation

Université :

Queen's University

Programme :

Business Strategy Internship

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