Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30156 projets achevés

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5059
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812
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673
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842
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8957
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9368
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96
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579
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1120
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Projets par catégorie

Computational Approaches for Characterizing Non-canonical Tandem Mass Spectra

Extensive research has been conducted for the computational analysis of mass spectrometry based proteomics data, however most of the traditional computational approaches take the assumption that the acquired spectra are generated from the fragmentation of a single precursor and the peptide is simply a linear sequence of amino acid residues. This ubiquitous assumption is impeding the utility of those computational approaches, especially when handling those non-canonical tandem mass spectra. In this project, we aim to develop new computational approaches for the interpretation of two types of non-canonical mass spectra, the mixture tandem mass spectra coming from the concurrent fragmentation of multiple precursors in one sequencing attempt, and the tandem mass spectra resulting from the sequencing of disulfide linkage structures. The software tools or integrated software modules developed in this project will potentially enhance the applications of the software packages and expand the commercial services provided by the partnering company.

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Superviseur du corps professoral :

Kaizhong Zhang

Étudiant :

Partenaire :

Bioinformatics Solutions Inc;Western University

Discipline :

Computer science

Secteur :

Information and cultural industries; Professional, scientific and technical services

Université :

Western University

Programme :

Elevate

Improving signal processing in hearing aids to support music and emotional speech – Year 2

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing aids restore the intelligibility but not the emotional content of speech, which is carried by acoustic cues that are similar to salient dimensions of music. This project aims to refine hearing aid processing for music and to assess whether signal processing can clarify the emotional content of speech without compromising intelligibility. The partner organization will benefit from the advancement of hearing aid technology to better support hearing in everyday life. In particular, these advancements may lead more people with hearing impairment to adopt hearing aids and result in greater adherence to hearing aid use.

Voir la description complète du projet
Superviseur du corps professoral :

Frank Russo

Étudiant :

Partenaire :

Unitron Hearing;Toronto Metropolitan University

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology

Université :

Toronto Metropolitan University

Programme :

Elevate

Improving signal processing in hearing aids to support music and emotional speech

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing aids restore the intelligibility but not the emotional content of speech, which is carried by acoustic cues that are similar to salient dimensions of music. This project aims to refine hearing aid processing for music and to assess whether signal processing can clarify the emotional content of speech without compromising intelligibility. The partner organization will benefit from the advancement of hearing aid technology to better support hearing in everyday life. In particular, these advancements may lead more people with hearing impairment to adopt hearing aids and result in greater adherence to hearing aid use.

Voir la description complète du projet
Superviseur du corps professoral :

Frank Russo

Étudiant :

Partenaire :

Unitron Hearing;Toronto Metropolitan University

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology

Université :

Toronto Metropolitan University

Programme :

Elevate

Towards the development of a Bayesian prognostic tool of air pollution in Ontario

Air pollution is a major concern in urban centers because not only does affect vulnerable populations, but also impacts the quality of life for urban dwellers. With the new implementation of the Air Quality Health Index (AQHI) by the Ontario Ministry of the Environment and Climate Change to replace the existing Ontario Air Quality Index (AQI), there is an emerging need to forecast future environmental impacts on air quality and assess the achievability of the newly-adopted index. This research will develop a risk-assessment methodological framework to project the trends of AQHI’s pollutant concentrations due to changes in atmospheric conditions resulting from climate change in Ontario. We will use a combination of Global Climate Models (GCMs) and Bayesian inference techniques to provide a novel risk-assessment tool that can effectively support policy analysis by the Provincial and Federal government to combat climate change.

Voir la description complète du projet
Superviseur du corps professoral :

Willam Gough

Étudiant :

Partenaire :

AEML Associates Ltd;University of Toronto Scarborough

Discipline :

Physics

Secteur :

Professional, scientific and technical services

Université :

University of Toronto Scarborough

Programme :

Elevate

Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy – Year 2

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation. Partner organization will benefit from our extensive knowledge and expertise in researching hypoxia as the laboratory of Dr. Wouters is a world renowned expert in the field. I have gained a lot of experience in development and analysis of 3D cellular systems during my PhD research that concentrated in stem cell biology. Overall, this fruitful collaboration will lead to development of new line of therapeutics that could help save lives of hundreds of thousands of suffering cancer patients worldwide.

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Superviseur du corps professoral :

Brad Garry Wouters

Étudiant :

Partenaire :

Northern Biologics Inc;University of Toronto

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation. Partner organization will benefit from our extensive knowledge and expertise in researching hypoxia as the laboratory of Dr. Wouters is a world renowned expert in the field. I have gained a lot of experience in development and analysis of 3D cellular systems during my PhD research that concentrated in stem cell biology. Overall, this fruitful collaboration will lead to development of new line of therapeutics that could help save lives of hundreds of thousands of suffering cancer patients worldwide.

Voir la description complète du projet
Superviseur du corps professoral :

Brad Garry Wouters

Étudiant :

Partenaire :

Northern Biologics Inc;University of Toronto

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Development of specific inhibitors and activators to assess the role of human Ephrin Receptors in health and disease

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of Eph receptors are extremely complex, and developing an effective therapeutic intervention for a particular disease requires a comprehensive understanding of Eph function. The goal of this project is to generate a collection of synthetic antibody molecules that block and activate every Eph receptor. This toolkit of antibody reagents will allow researchers to identify the best approach for targeting Eph receptors individually or in combination to counteract a particular disease state. This collection of Eph-modulating antibody reagents will expand the existing antibody portfolio of the Centre for the Commercialization of Antibodies and Biologics (CCAB).

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Superviseur du corps professoral :

Jason Moffat

Étudiant :

Partenaire :

Centre for the Commercialization of Antibodies and Biologics;University of Toronto

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Développement d’une caméra grand angle miniature

Parmi les systèmes optiques, les lentilles ayant un très grand champ de vue, dites panoramiques, sont des dispositifs extrêmement difficiles à miniaturiser, notamment à cause de leur nombre d’éléments optiques, leur forme et leur complexité. Les techniques actuelles de miniaturisation, utilisées avec succès pour les optiques de téléphones cellulaires, ne permettent pas de miniaturiser suffisamment la lentille grand angle classique. Ces systèmes sont pourtant utiles dans de nombreux domaines puisqu’ils permettent d’emmagasiner de l’information sur une grande portion de l’espace environnant, diminuant le besoin en mouvement et en captures multiples. En s’inspirant de certaines propriétés optiques retrouvées chez l’oeil humain, il est possible de développer des systèmes grand angle beaucoup plus compact, adaptés à des applications précises en imagerie médicale ou en inspection. L’objectif de ce stage sera précisément le développement de ce genre d’outil dans le but de répondre à des problématiques concrètes.

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Superviseur du corps professoral :

Simon Thibault

Étudiant :

Partenaire :

6115187 Canada Inc

Discipline :

Physics

Secteur :

Professional, scientific and technical services

Université :

Université Laval

Programme :

Accelerate

Development and validation of a tool for the measurement of hearing aid sound quality

Hearing aids are now fully digital, advanced signal processors. Studies show that the sound quality of today’s hearing aids is important, and may impact how a hearing aid user enjoys music. Few tools are available for clinicians to measure hearing aid sound quality in daily practice. In this project, we will develop and implement a tool for this purpose.

Voir la description complète du projet
Superviseur du corps professoral :

Susan Scollie

Étudiant :

Partenaire :

Audioscan

Discipline :

Life Sciences

Secteur :

Manufacturing

Université :

Western University

Programme :

Accelerate

CYPRESS Video Analytic Framework

High definition acquisition devices have been commonly used in video capture. Millions of videos are recorded and stored daily. Due to the rapidly growing volume, effectively searching and matching the desired video clips from archives has become increasingly challenging. It may need days and weeks to locate the target information, such as suspected criminals, traffic violated vehicles, or accidental fall in care homes. While Google engine is designed for web searching, we propose to build a framework for efficient video searching. We will evaluate various approaches, in particular state-of-the-art machine learning techniques, parallel computing, real-time transmission and big data storage. By exploiting these technologies, we expect to deliver a real-time video searching and matching system, which is robust and can be deployed in a large application domain.

Voir la description complète du projet
Superviseur du corps professoral :

Irene Cheng

Étudiant :

Partenaire :

Istuary Innovation Labs Inc (Vancouver, BC);Eyexpo Technology Corp;eChaperone.AI

Discipline :

Computer science

Secteur :

Professional, scientific and technical services

Université :

University of Alberta

Programme :

Accelerate

Adapting methods for assessing the impacts of innovation support programs for application to Canada’s clean energy innovation ecosystem

This research project is being undertaken in partnership with The Evidence Network Inc. It will extend the company’s scientifically-based method of assessing the impact of innovation support programs to the clean energy innovation sector. To keep this kind of assessment method scientifically sound requires customization for each particular industry. The established methods have been widely applied in the IT and medical fields, but not yet in the energy sector. When assessing success in a new sector, it is critical to account for differences in program goals, stakeholders, and the nature of the sector – as this project will do. As Canada increases it commitment to clean energy innovation, this project will help The Evidence Network extend its services to this sector and contribute to making our clean energy innovation support programs more effective.

Voir la description complète du projet
Superviseur du corps professoral :

Jatin Nathwani

Étudiant :

Partenaire :

The Evidence Network Inc

Discipline :

Sociology

Secteur :

Professional, scientific and technical services

Université :

University of Waterloo

Programme :

Accelerate

Deciphering the role of the tumor suppressor p53 in regulating treatment-induced ovarian cancer cell fate decisions in vivo

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that current chemotherapy protocols induce a very interesting phenomenon – cellular senescence – in treated cells. Senescence is thought to be beneficial in cancer therapy under certain conditions. We would like to explore the mechanisms of this senescent response to treatment in ovarian cancer and to manipulate it to benefit patients.

Voir la description complète du projet
Superviseur du corps professoral :

Francis Rodier

Étudiant :

Partenaire :

Institut du cancer de Montréal

Discipline :

Life Sciences

Secteur :

Other services (except public administration); Professional, scientific and technical services

Université :

Université de Montréal

Programme :

Accelerate

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