Projets novateurs réalisés

Explorez des milliers de projets réussis issus de la collaboration entre organisations et talents postsecondaires.

30156 projets achevés

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Projets par catégorie

Neural and autonomic correlates of post-traumatic stress disorder during processing of trauma-related stimuli

Post-traumatic stress disorder (PTSD) emerges after the exposure to an event that elicits horror or helplessness, including threat of injury or death to one’s self or another person. Community-based studies have evaluated its occurrence with a lifetime prevalence of 9.2% in the Canadian population. This research project aims to develop innovative, neural-substrate based, and novel theoretical paradigms for understanding psychological trauma and its clinical outcomes, including problems in emotion regulation, self-awareness, social emotional and self-referential processing. Cuttingedge neuroimaging analyses will be utilized to compare the response of individuals with and without PTSD, with the ultimate goal of significantly improving treatment of PTSD. The implementation of advanced neuroimaging methodologies and the translation of evidence-based outcomes into clinical knowledge will benefit the partner organization as well as the health services providing treatment of PTSD. Dissemination of the results will also constitute an indirect benefit for all the parties involved.

Voir la description complète du projet
Superviseur du corps professoral :

Ruth Lanius

Étudiant :

Partenaire :

Homewood Health Centre;Homewood Research Institute

Discipline :

Life Sciences

Secteur :

Health and Related Sciences & Technology; Professional, scientific and technical services

Université :

Western University

Programme :

Accelerate

The effect of an innovative parent training program to promote parental reflective function and child development in high-risk families

Parents suffering from toxic stress (depression, addictions, and/or family violence) are often unable to respond sensitively and appropriately to their infants, putting the health and development of their infants at risk. My research evaluates a new parenting program called ATTACH. In ATTACH, parents learn to reflect on how they parent and to better understand their own feelings and behavior and those of their children. We hope that ATTACH improves parents’ sensitivity and responsiveness to their infants and ultimately their children’s health and development. I will conduct this study with Calgary Urban Project Society (CUPS) that provides services to high-risk families. If effective, I expect this new ATTACH program will be commercializable and added to service agencies’ programs for high-risk families, such as CUPS. The Norlien Foundation is also a partner and study results directly address Norlien’s vision of supporting research and accelerating innovation to improve children’s health and development.

Voir la description complète du projet
Superviseur du corps professoral :

Nicole LeTourneau

Étudiant :

Partenaire :

Calgary Urban Project Society;Norlien Foundation

Discipline :

Life Sciences

Secteur :

Other services (except public administration)

Université :

University of Calgary

Programme :

Accelerate

Versatile applications of a safe and efficient peptide in gene/drug delivery – Year Two

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will cause severe side effects when used in human. The new peptide based delivery system we developed demonstrated better performance and lower toxicity than the commercialized product on market. Preliminary animal experiments also proved the great therapeutic potential of this novel peptide. Now we propose to further confirm the efficiency of this peptide on various cells from different tissues, as well as to extend the application to deliver other therapeutic molecules. The partner organization will benefit from the potential of commercializing a product with bright market prospect and promising therapeutic applications.

Voir la description complète du projet
Superviseur du corps professoral :

Pu Chen

Étudiant :

Partenaire :

Positec Canada Ltd

Discipline :

Engineering

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

University of Waterloo

Programme :

Elevate

New strategies to improve the use of the predatory bug, Orius insidiosus, to control Western Flower Thrips, Frankliniella occidentalis, in greenhouse ornamental crops

The proposed research will investigate how to improve the performance and economic sustainability of Orius insidiosus as a biological control against Western Flower Thrips in greenhouse ornamental crops. New strategies to increase the efficiency of O. insidious will be investigated through the use of banker plants, supplemental food, and the use of lures. The project complements previous thrips research and will contribute to increased greenhouse production and profitability. Additionally, while the proposed research is targeted towards floriculture, there may be applicable uses for control in greenhouse vegetable and field crops as well. The research aligns closely with Eco Habitat Agri Services objectives of integration and implementation of biological control strategies in greenhouse oranmental crops. Results from this research will help develop company recommendations for greenhouse growers to ensure their biological control strategies are more reliable and economical.

Voir la description complète du projet
Superviseur du corps professoral :

Cynthia Scott-Dupree

Étudiant :

Partenaire :

Discipline :

Life Sciences

Secteur :

Université :

University of Guelph

Programme :

Accelerate

Versatile applications of a safe and efficient peptide in gene/drug delivery

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will cause severe side effects when used in human. The new peptide based delivery system we developed demonstrated better performance and lower toxicity than the commercialized product on market. Preliminary animal experiments also proved the great therapeutic potential of this novel peptide. Now we propose to further confirm the efficiency of this peptide on various cells from different tissues, as well as to extend the application to deliver other therapeutic molecules. The partner organization will benefit from the potential of commercializing a product with bright market prospect and promising therapeutic applications.

Voir la description complète du projet
Superviseur du corps professoral :

Pu Chen

Étudiant :

Partenaire :

Positec Canada Ltd

Discipline :

Engineering

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

University of Waterloo

Programme :

Elevate

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases – Year Two

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes. Unfortunately, the lack of molecules that can block the activity of viral deubiquitinases has severely hampered attempts to manipulate them for therapeutic benefits. The Sidhu group has invented a new technology to develop synthetic protein modulators for any ubiquitin-interacting proteins. The goal of this project is to generate highly specific and potent inhibitors for viral pathogenic deubiquitinases and a platform to deliver these molecules into human cells. This will lead to effective antiviral therapy, expanding the existing therapeutic portfolio of CCAB.

Voir la description complète du projet
Superviseur du corps professoral :

Jason Moffat

Étudiant :

Partenaire :

Centre for the Commercialization of Antibodies and Biologics

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes. Unfortunately, the lack of molecules that can block the activity of viral deubiquitinases has severely hampered attempts to manipulate them for therapeutic benefits. The Sidhu group has invented a new technology to develop synthetic protein modulators for any ubiquitin-interacting proteins. The goal of this project is to generate highly specific and potent inhibitors for viral pathogenic deubiquitinases and a platform to deliver these molecules into human cells. This will lead to effective antiviral therapy, expanding the existing therapeutic portfolio of CCAB.

Voir la description complète du projet
Superviseur du corps professoral :

Jason Moffat

Étudiant :

Partenaire :

Centre for the Commercialization of Antibodies and Biologics

Discipline :

Life Sciences

Secteur :

Professional, scientific and technical services

Université :

University of Toronto

Programme :

Elevate

Ergo4all (Caractérisation des usagers types de DHM)

Les logiciels actuels de DHM (Digital Human Modeling ou d’ergonomie virtuelle) destinés à la conception ergonomique de situations de travail et de produits demeurent difficiles à utiliser ce qui en limite grandement l’utilisation par les concepteurs et les ergonomes. Pourtant, l’utilisation plus répandue de DHM permettrait d’en arriver à des environnements de travail plus sécuritaires et minimisant les risques pour la santé des travailleurs. Il apparaît donc utile de concevoir les logiciels de DHM en tenant compte des caractéristiques et exigences de leurs utilisateurs (i.e., conception centrée sur l’opérateur humain). Or, les types d’utilisateurs actuels et potentiels de DHM sont très variés et la littérature actuelle ne fournit aucune information permettant de les caractériser, ce qui constitue une lacune importante. L’objectif du projet présenté ici consiste donc à caractériser des utilisateurs types d’un nouveau logiciel DHM en voie de développement chez DS et ce, en vue de s’assurer que ce nouveau logiciel réponde bien aux exigences de ces utilisateurs, concepteurs et ergonomes.

Voir la description complète du projet
Superviseur du corps professoral :

Daniel Imbeau

Étudiant :

Partenaire :

Dassault Systèmes

Discipline :

Physics

Secteur :

Aerospace; Automotive; Technology

Université :

École Polytechnique de Montréal

Programme :

Accelerate

Development of Standardized Laboratory and Semi-Field Methods for Assessing the Risk of Pesticide Exposure to Megachile rotundata F. – Year Two

Non-Apis bees are now recognized as significant pollinators. For most crops visited by bees, pesticides are used for pest management, and there is concern about the potential negative effects of pesticides on wild and managed bees. Most toxicity studies involving bees have focused on honey bees (Apis mellifera), partially because honey bee data are required for pesticide registration. Yet because of physiological and behavioural differences, honey bees and non-Apis bees may not be equally susceptible to a given pesticide. As such, there is interest from regulatory agencies in incorporating non-Apis bees into pesticide risk assessments. However, methods for assessing the hazards of pesticides to non-Apis bees have not yet been established. We aim to generate data that will contribute to the development of standardized methods for assessing the risk of pesticides to alfalfa leafcutter bees (Megachile rotundata), one of the most intensively managed non-Apis bees for agricultural pollination in Canada.

Voir la description complète du projet
Superviseur du corps professoral :

Cynthia Scott-Dupree

Étudiant :

Partenaire :

Syngenta Canada Inc.

Discipline :

Life Sciences

Secteur :

Agriculture and Food; Sustainability & the Environment; Life Sciences (not health)

Université :

University of Guelph

Programme :

Elevate

Development of Standardized Laboratory and Semi-Field Methods for Assessing the Risk of Pesticide Exposure to Megachile rotundata F.

Non-Apis bees are now recognized as significant pollinators. For most crops visited by bees, pesticides are used for pest management, and there is concern about the potential negative effects of pesticides on wild and managed bees. Most toxicity studies involving bees have focused on honey bees (Apis mellifera), partially because honey bee data are required for pesticide registration. Yet because of physiological and behavioural differences, honey bees and non-Apis bees may not be equally susceptible to a given pesticide. As such, there is interest from regulatory agencies in incorporating non-Apis bees into pesticide risk assessments. However, methods for assessing the hazards of pesticides to non-Apis bees have not yet been established. We aim to generate data that will contribute to the development of standardized methods for assessing the risk of pesticides to alfalfa leafcutter bees (Megachile rotundata), one of the most intensively managed non-Apis bees for agricultural pollination in Canada.

Voir la description complète du projet
Superviseur du corps professoral :

Cynthia Scott-Dupree

Étudiant :

Partenaire :

Syngenta Canada Inc.

Discipline :

Life Sciences

Secteur :

Sustainability & the Environment; Agriculture and Food; Life Sciences (not health)

Université :

University of Guelph

Programme :

Elevate

Contribution à l’optimisation des opérations de maintenance basée sur la fiabilité en fatigue des turbines hydrauliques

Ce projet a pour but de proposer aux gestionnaires des centrales hydro-électriques d’Hydro-Québec des solutions d’organisation de la maintenance de turbine hydro-électrique à partir d’un indice prédisant l’état futur de la turbine. Cette organisation prendra en compte plusieurs aspects tels que la problématique liée à la demande en énergie (certaines périodes sont plus propices que d’autres aux maintenances), la disponibilité de l’équipement, le surcoût d’un report de l’intervention, le coût de l’inspection, l’impact de l’intervention sur l’indice, etc. Une telle organisation permettra une réduction des coûts (considérés comme la perte de bénéfice), par la compréhension et l’anticipation des conséquences des décisions.

Voir la description complète du projet
Superviseur du corps professoral :

Souheil-Antoine Tahan

Étudiant :

Partenaire :

Institut de Recherche Hydro-Québec

Discipline :

Engineering

Secteur :

Professional, scientific and technical services; Utilities

Université :

École de technologie supérieure

Programme :

Accelerate

Development of Monoclonal Antibodies and Rapid Lateral Flow Test Kit for the Specific Detection of Streptococcus agalactiae

Streptococcus agalactiae (S. agalactiae) is a worldwide-distributed bacterium. It is a major infectious agent to humans, cattle and aquatic animals. The outbreak and prevalence of S. agalactiae in aquaculture has been reported in different countries as one of the major causes of mortality leading to serious economic losses and threatening the sound development of aquaculture. The current methods for detection of S. agalactiae are time-consuming and require specific equipment and technical training. Therefore we will develop a diagnostic test for the simple, rapid and early detection of the disease caused by S. agalactiae in aquaculture. The antibody-based test will provide an answer within seconds. This test will facilitate the breaking of Artron Bioresearch into the fish-industry market and will position Artron as a successful and reliable company for the development of diagnostic tests for aquaculture. The growth of Artron will in turn create more employment opportunities in the biotechnology sector.

Voir la description complète du projet
Superviseur du corps professoral :

Horacio Bach

Étudiant :

Partenaire :

Artron Bioresearch Inc

Discipline :

Life Sciences

Secteur :

Manufacturing; Professional, scientific and technical services

Université :

The University of British Columbia

Programme :

Elevate

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