Biological clustering of pulmonary exacerbations in CF (BIOPEX-CF)

Cystic fibrosis is a genetic disorder that leads to acute episodes of worsening respiratory symptoms termed pulmonary exacerbations (PEx). The current PEx treatment paradigm involves using oral or intravenous antibiotics under the assumption that all of these episodes are caused by worsening bacterial infection, but PEx can also be attributed to viral infections, air pollution, allergens, and treatment non-adherence. In collaboration with the PRevention Of Organ Failure Centre of Excellence (PROOF), we aim to group PEx based on circulating molecular data (proteins, RNA) that more accurately reflects the biology of the PEx. This important knowledge imparted from this project will pave the way for more specific and effective PEx treatment strategies. This project will benefit the PROOF Centre as the molecular data can be used to develop blood-based biomarkers to advance their mandate of providing biomarker solutions for health care.

Faculty Supervisor:

Bradley Quon

Student:

Partner:

PROOF Centre of Excellence

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Professional, scientific and technical services

University:

The University of British Columbia

Program: