Chemiluminescence-Resonance Energy Transfer Strategies for Next Generation Photodynamic Therapy

This research project aims to develop new molecular systems that can produce light directly inside biological tissues, allowing diseases such as cancer to be detected and treated without the need for an external light source. Conventional light-based therapies are limited because light does not penetrate deeply into the body, reducing their effectiveness for internal or hard-to-reach tumors. To overcome this limitation, the project focuses on chemiluminescent reactions, which are chemical processes that generate light through reactions triggered by biological conditions found in cancer cells.

The goal is to design integrated systems capable of chemiluminescence resonance energy transfer (CRET) by chemically engineering chemiluminescent reagents and BTI photosensitizers so that they are fully compatible. Rather than simply mixing components, the project aims to ensure efficient energy transfer between them, allowing the internally generated light to activate BTI photosensitizers. Once activated, these molecules can produce reactive species that destroy diseased cells through photodynamic therapy while minimizing damage to healthy tissues.

By combining chemistry, light-based science, and biomedical applications, this work seeks to overcome key limitations of current light-based treatments and could contribute to safer and more effective therapeutic strategies in cancer medicine.

Faculty Supervisor:

Gregory Welch

Student:

Partner:

Université d'Angers

Discipline:

Physics

Sector:

Health and Related Sciences & Technology

University:

University of Calgary

Program: