Controlling inhaled gasses for novel clinicalapplications

The general objective of this MITACS project is to introduce RespirAct (TM) as a unique device that provides a precise, repeatable vasoactive stimulus to extend the capabilities of imaging modalitites such as PET, CT, MRI and ultrasound. In the first project, the development and standardization of the cerebrovascular stress test will provde a means to assess impaired cerebrovascular control in clinical as well as research settings. In the second project, the mechanism of cerebral white matter injury will be explored using the RespirAct technology. THe third project will focus on demonstrating the efficacy of hydrogen gas in DNA protection and to standardize a gas delivery technology for safe hydrogen gas inhalation during diagnostic imaging tests. The studies the interns will be performing are indespensible to enable the RespirAct (TM) to be applied to patients. The experience in this validation will both guide the development of the clinical device and provide validation for its clinical adoption.

Faculty Supervisor:

David Mikulis

Student:

Partner:

Thornhill Research Inc

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Toronto

Program: