Designing cross-species-reactive compact promoters for targeting specific cell types in the body

The interns will first conduct market research to determine the demands of the current life sciences industry, including pharmaceutical companies, gene therapy development companies, and companies that offer transgenic animal models. With this data, the interns will work together using a proprietary machine-learning algorithm from Re:Pair Genomics to design a catalog of 5-10 different compact, synthetic DNA sequences used to target different brain cells, heart cells, and cancer cells. These DNA sequences are predicted as compactible with mice, monkeys, and humans. These synthetic sequences will be tested at a wet lab facility at Re:Pair Genomics, and the data will be used to refine the software model. In addition, the interns will work with legal experts to search for various IP strategies and the patentability of these synthetic DNA sequences. Re:Pair Genomics will then commercialize this catalog of synthetic DNA sequences for research in the life sciences and gene therapy field.

Faculty Supervisor:

Keith Pardee

Student:

Partner:

Re:Pair Genomics Inc.

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: