Development of a Novel Dicalcium Phosphate Cement-Based Construct [Brushite-Shell/Monetite-Core] for Controlled Degradation and Drug Release in Craniofacial Defect Repair Surgery

Craniofacial and maxillofacial reconstruction is often limited by insufficient autologous bone and the shortcomings of current graft alternatives, which can degrade unevenly, bond poorly, or fail to support vascular growth. These issues are especially critical in cases of trauma, congenital defects, or cancer-related bone loss, where reliable, bioresorbable grafts are essential. This project evaluates and adapts Brushite-Shell/Monetite-Core calcium phosphate scaffolds for craniofacial, maxillofacial, and reconstructive surgery. Brushite (CaHPO4·2H2O) transforms into a more stable phase, slowing resorption, while monetite (CaHPO4) degrades faster, supporting early bone regeneration. Combining them enables controlled resorption and improved integration, and the monetite core can also be modified to deliver natural growth factors that promote bone and vessel formation. The aim of this project is to determine where this hybrid material provides the greatest clinical benefit and what design adaptations are needed for surgical use. The collaboration between Dalhousie University and the University of Illinois Health connects biomaterial innovation with clinical translation; Dalhousie focusing on material design, fabrication, and testing, and Illinois advancing understanding of clinical needs and real-world applications. This partnership will strengthen research collaboration, promote knowledge exchange, and support the development of safer, more effective bone grafts to improve outcomes in craniofacial and maxillofacial reconstruction.

Faculty Supervisor:

Zeeshan Sheikh

Student:

Partner:

University of Illinois Health

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

Dalhousie University

Program: