Evaluation of the mechanistic interplay between psychobiotic microbes and human gut microbiota challenged with psychotropic chemicals.

Several classes of psychotropic compounds have been increasingly shown to possess antimicrobial properties with possible implication in microbiota-gut-brain axis. For instance, sertraline and paroxetine are efflux inhibitors in bacteria cell walls and are effective on gram-positive bacteria such as Enterococcus and Staphylococcus. Therefore, a comprehensive assessment of the antimicrobial effect of these chemicals on gut commensal bacteria and consumed probiotics will provide critical insight for the design of robust new nutraceuticals. This project will provide essential data prerequisite to the potential application of probiotics for prevention of gut dysbiosis, specifically in response to psychotropic chemicals..

Faculty Supervisor:

Riadh Hammami

Student:

Partner:

Lallemand Bio Ingredients

Discipline:

Life Sciences

Sector:

Manufacturing

University:

University of Ottawa

Program: